Phorbol 12,13-diacetate

Base Information Edit

Chemical Name:Phorbol 12,13-diacetate
CAS No.:24928-15-2
Molecular Formula:C₂₄H₃₂O₈
Molecular Weight:448.513
Hs Code.:2915290000
European Community (EC) Number:636-718-1
DSSTox Substance ID:DTXSID80947808
Nikkaji Number:J39.188C
Wikidata:Q82925628
ChEMBL ID:CHEMBL116437
Mol file:24928-15-2.mol

Synonyms:4 beta-phorbol-12,13-diacetate;phorbol 12,13-diacetate;phorbol-10,11-diacetate;phorbol-12,13-diacetate;phorbol-12,13-diacetate, (1aR-(1aalpha,1bbeta,4abeta,7abeta,7balpha,8alpha,9beta,9aalpha))-isomer

Suppliers and Price of Phorbol 12,13-diacetate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
Phorbol 12,13-diacetate powder
5mg
$ 215.00

Sigma-Aldrich
Phorbol 12,13-diacetate powder
1mg
$ 74.60

AHH
Phorbol 12,13-diacetate 95%
0.01g
$ 298.00

Total 9 raw suppliers

Chemical Property of Phorbol 12,13-diacetate Edit

Chemical Property:

Vapor Pressure:3.69E-16mmHg at 25°C
Refractive Index:1.4480 (estimate)
Boiling Point:585.7°C at 760 mmHg
Flash Point:195.4°C
Density:1.34g/cm³
Storage Temp.:−20°C
Solubility.:H2O: soluble
XLogP3:0.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:448.20971797
Heavy Atom Count:32
Complexity:963

Purity/Quality:

98%,99%, ^*data from raw suppliers

Phorbol 12,13-diacetate powder ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T+
Statements: 26/27/28-36/37/38
Safety Statements: 26-27-36/37/39-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1C(C2(C(C2(C)C)C3C1(C4C=C(C(=O)C4(CC(=C3)CO)O)C)O)OC(=O)C)OC(=O)C
Isomeric SMILES:C[C@@H]1[C@H]([C@@]2([C@@H](C2(C)C)[C@H]3[C@]1([C@@H]4C=C(C(=O)[C@]4(CC(=C3)CO)O)C)O)OC(=O)C)OC(=O)C
Uses Phorbol 12,13-diacetate may be used to stimulate protein kinase C (PKC) for phosphorylation of retinal proteins.

Technology Process of Phorbol 12,13-diacetate

There total 5 articles about Phorbol 12,13-diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 77495-83-1
phorbol 12,13-diacetate-20-trityl

: 24928-15-2
Phorbol 12,13-diacetate

Guidance literature:: With perchloric acid; In methanol; at 20 ℃; for 0.5h;
DOI:10.1021/acs.jmedchem.1c00156

Reference yield: 84.0%

: 82400-03-1
phorbol-20-trityl ether

: 64-19-7,77671-22-8
acetic acid

: 24928-15-2
Phorbol 12,13-diacetate

Guidance literature:: phorbol-20-trityl ether; acetic acid; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

With perchloric acid; In methanol; for 1h;
DOI:10.1016/j.bmcl.2021.128319