Technology Process of 4-((4-(3-(trifluoromethyl)phenyl)piperidin-3-yl)amino)benzo[d][1,2,3]triazine-8-carboxamide
There total 5 articles about 4-((4-(3-(trifluoromethyl)phenyl)piperidin-3-yl)amino)benzo[d][1,2,3]triazine-8-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane; methanol;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium nitrite; hydrogenchloride / N,N-dimethyl-formamide / 2 h / 0 - 20 °C
2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 18 h / 50 °C / Inert atmosphere
3: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 20 °C
With
hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium nitrite;
In
1,4-dioxane; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydroxide; potassium permanganate / water / 23 h / 90 °C
2.1: thionyl chloride / N,N-dimethyl-formamide / 16 h / Inert atmosphere; Reflux
2.2: 6 h / 0 - 20 °C
3.1: palladium on activated charcoal; hydrogen / N,N-dimethyl-formamide / 16 h / 20 °C
4.1: sodium nitrite; hydrogenchloride / N,N-dimethyl-formamide / 2 h / 0 - 20 °C
5.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 18 h / 50 °C / Inert atmosphere
6.1: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 20 °C
With
hydrogenchloride; potassium permanganate; thionyl chloride; palladium on activated charcoal; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sodium nitrite;
In
1,4-dioxane; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
