2-{2-(2-methoxyethoxy)ethoxy}-1-phenylmethynol

Base Information

• Chemical Name: 2-{2-(2-methoxyethoxy)ethoxy}-1-phenylmethynol
• CAS No.: 1342493-70-2
• Molecular Formula: C₁₂H₁₈O₄
• Molecular Weight: 226.273
• Mol file: 1342493-70-2.mol

Synonyms:2-{2-(2-methoxyethoxy)ethoxy}-1-phenylmethynol

Chemical Property of 2-{2-(2-methoxyethoxy)ethoxy}-1-phenylmethynol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{2-(2-methoxyethoxy)ethoxy}-1-phenylmethynol

There total 2 articles about 2-{2-(2-methoxyethoxy)ethoxy}-1-phenylmethynol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.2%

salicylic alcohol (90-01-7) + toluene-4-sulfonic acid 2-(2-methoxyethoxy)ethyl ester (50586-80-6,58320-73-3) → 2-{2-(2-methoxyethoxy)ethoxy}-1-phenylmethynol (1342493-70-2)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In acetone; at 0 ℃; for 48h; Reflux; Inert atmosphere;

DOI:10.1016/j.polymer.2013.11.046

Reference yield:

2-(2-methoxyethoxy)ethyl alcohol (111-77-3,95507-80-5) → 2-{2-(2-methoxyethoxy)ethoxy}-1-phenylmethynol (1342493-70-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran / 9 h / 0 - 20 °C

2: potassium carbonate; 18-crown-6 ether / acetone / 48 h / 0 °C / Reflux

With 18-crown-6 ether; sodium hydride; potassium carbonate; In tetrahydrofuran; acetone;

DOI:10.1246/cl.130372

Reference yield:

2-{2-(2-methoxyethoxy)ethoxy}-1-phenylmethynol (1342493-70-2) → (5-ethylnyl-2-((2-(2-(2-methoxyethoxy)ethoxy)benzyl)oxy)-1,3-phenylene)dimethanol (1485487-62-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine; carbon tetrabromide / dichloromethane / 1 h / 0 °C / Inert atmosphere

2: potassium carbonate; 18-crown-6 ether / acetone / 48 h / 0 °C / Reflux; Inert atmosphere

With 18-crown-6 ether; carbon tetrabromide; potassium carbonate; triphenylphosphine; In dichloromethane; acetone;

DOI:10.1016/j.polymer.2013.11.046

upstream raw materials:

2-(2-methoxyethoxy)ethyl alcohol

salicylic alcohol

toluene-4-sulfonic acid 2-(2-methoxyethoxy)ethyl ester

Downstream raw materials:

(5-ethylnyl-2-((2-(2-(2-methoxyethoxy)ethoxy)benzyl)oxy)-1,3-phenylene)dimethanol