[3,4-Bis(difluoromethoxy)phenyl]-[6-(1-methyl-1-phenylethylamino)3-pyridyl]methanone

Base Information

• Chemical Name: [3,4-Bis(difluoromethoxy)phenyl]-[6-(1-methyl-1-phenylethylamino)3-pyridyl]methanone
• CAS No.: 306761-00-2
• Molecular Formula: C₂₃H₂₀F₄N₂O₃
• Molecular Weight: 448.417

Synonyms:[3,4-Bis(difluoromethoxy)phenyl]-[6-(1-methyl-1-phenylethylamino)3-pyridyl]methanone

Chemical Property of [3,4-Bis(difluoromethoxy)phenyl]-[6-(1-methyl-1-phenylethylamino)3-pyridyl]methanone

Chemical Property:

Purity/Quality:

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Technology Process of [3,4-Bis(difluoromethoxy)phenyl]-[6-(1-methyl-1-phenylethylamino)3-pyridyl]methanone

There total 5 articles about [3,4-Bis(difluoromethoxy)phenyl]-[6-(1-methyl-1-phenylethylamino)3-pyridyl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-phenyl-2-propylamine (585-32-0) + [3,4-Bis(difluoromethoxy)phenyl]-(6-bromo-pyridin-3-yl)methanone (303165-21-1) → [3,4-Bis(difluoromethoxy)phenyl]-[6-(1-methyl-1-phenylethylamino)3-pyridyl]methanone (306761-00-2)

Guidance literature:

With copper(l) iodide; at 140 ℃;

DOI:10.1016/S0960-894X(02)01030-2

Reference yield:

2,5-dibromopyridine (624-28-2) → [3,4-Bis(difluoromethoxy)phenyl]-[6-(1-methyl-1-phenylethylamino)3-pyridyl]methanone (306761-00-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 53 percent / BuLi / diethyl ether / -78 °C

2: 88 percent / MnO₂ / CH₂Cl₂

3: 89 percent / CuI / 140 °C

With manganese(IV) oxide; copper(l) iodide; n-butyllithium; In diethyl ether; dichloromethane;

DOI:10.1016/S0960-894X(02)01030-2

Reference yield:

3,4-bis-(difluoromethoxy)-benzaldehyde (127842-54-0) → [3,4-Bis(difluoromethoxy)phenyl]-[6-(1-methyl-1-phenylethylamino)3-pyridyl]methanone (306761-00-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 53 percent / BuLi / diethyl ether / -78 °C

2: 88 percent / MnO₂ / CH₂Cl₂

3: 89 percent / CuI / 140 °C

With manganese(IV) oxide; copper(l) iodide; n-butyllithium; In diethyl ether; dichloromethane;

DOI:10.1016/S0960-894X(02)01030-2

upstream raw materials:

2-phenyl-2-propylamine

[3,4-Bis(difluoromethoxy)phenyl]-(6-bromo-pyridin-3-yl)methanone

2,5-dibromopyridine

3,4-bis-(difluoromethoxy)-benzaldehyde

Downstream raw materials:

{5-[1-(3,4-bis-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-ethyl]-pyridin-2-yl}-(1-methyl-1-phenyl-ethyl)-carbamic acid benzyl ester

{5-[1-(3,4-bis-difluoromethoxy-phenyl)-2-pyridin-4-yl-ethyl]-pyridin-2-yl}-(1-methyl-1-phenyl-ethyl)-carbamic acid benzyl ester

{5-[(3,4-bis-difluoromethoxy-phenyl)-hydroxy-methyl]-pyridin-2-yl}-(1-methyl-1-phenyl-ethyl)-carbamic acid benzyl ester

{5-[1-(3,4-bis-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-ethyl]-pyridin-2-yl}-(1-methyl-1-phenyl-ethyl)-amine

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