3,4-Bis(difluoromethoxy)benzaldehyde

Base Information

Chemical Name:3,4-Bis(difluoromethoxy)benzaldehyde
CAS No.:127842-54-0
Molecular Formula:C9H6F4O3
Molecular Weight:238.138
Hs Code.:2913000090
DSSTox Substance ID:DTXSID40561105
Nikkaji Number:J1.729.115G
Wikidata:Q72445002
Mol file:127842-54-0.mol

Synonyms:3,4-BIS(DIFLUOROMETHOXY)BENZALDEHYDE;127842-54-0;3,4-Bis-difluoromethoxy-benzaldehyde;Benzaldehyde, 3,4-bis(difluoromethoxy)-;MFCD08706075;3,4-Bis-difluoromethoxybenzaldehyde;SCHEMBL140841;AMY2986;DTXSID40561105;3,4-Bisdifluoromethoxybenzaldehyde;CL8294;AKOS015969250;AC-28483;AS-18812;SY028767;CS-0028734;3 pound not4-Bis(difluoromethoxy)benzaldehyde;A23460;EN300-7382141;Z2044798570

Suppliers and Price of 3,4-Bis(difluoromethoxy)benzaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3,4-Bis(difluoromethoxy)benzaldehyde
10g
$ 950.00

Medical Isotopes, Inc.
3,4-Bis(difluoromethoxy)benzaldehyde
1 g
$ 620.00

Crysdot
3,4-Bis(difluoromethoxy)benzaldehyde 98%
25g
$ 161.00

AK Scientific
3,4-Bis(difluoromethoxy)benzaldehyde
5g
$ 45.00

AK Scientific
3,4-Bis(difluoromethoxy)benzaldehyde
1g
$ 21.00

Total 47 raw suppliers

Chemical Property of 3,4-Bis(difluoromethoxy)benzaldehyde

Chemical Property:

Boiling Point:265.8±35.0℃ (760 Torr)
Flash Point:111.1±20.8℃
PSA：35.53000
Density:1.387±0.06 g/cm3 (20 ºC 760 Torr)
LogP:2.70190
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:238.02530670
Heavy Atom Count:16
Complexity:225

Purity/Quality:

98% ^*data from raw suppliers

3,4-Bis(difluoromethoxy)benzaldehyde ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C=C1C=O)OC(F)F)OC(F)F
Uses 3,4-Bis(difluoromethoxy)benzaldehyde is an impurity of the antiasthmatic drug Roflumilast (R639700). 3,4-Bis(difluoromethoxy)benzaldehyde is used in the preparation of diphenylethylene compounds as PDE4 (phosphodiesterase-4) inhibitors for treatment of cancer, CNS disorders, and inflammatory disorders.

Technology Process of 3,4-Bis(difluoromethoxy)benzaldehyde

There total 8 articles about 3,4-Bis(difluoromethoxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1895-39-2
sodium chlorodifluoroacetate

: 139-85-5
3,4-dihydroxybenzaldehyde

: 127842-54-0
3,4-bis-(difluoromethoxy)-benzaldehyde

Guidance literature:: sodium chlorodifluoroacetate; 3,4-dihydroxybenzaldehyde; With potassium carbonate; In water; N,N-dimethyl-formamide; at 100 ℃; for 2h;

With hydrogenchloride; In water; N,N-dimethyl-formamide;

With sodium hydroxide; In water; N,N-dimethyl-formamide; pH=> 9;