(3-{6-benzyloxy-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-8-ylamino}-phenyl)-phenyl-methanone

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Chemical Name:(3-{6-benzyloxy-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-8-ylamino}-phenyl)-phenyl-methanone
CAS No.:479408-29-2
Molecular Formula:C₆₃H₇₄N₆O₇Si₂
Molecular Weight:1083.49
Hs Code.:

(3-{6-benzyloxy-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-9-[4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-5-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9<i>H</i>-purin-8-ylamino}-phenyl)-phenyl-methanone

Synonyms:(3-{6-benzyloxy-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-8-ylamino}-phenyl)-phenyl-methanone

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Chemical Property of (3-{6-benzyloxy-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-8-ylamino}-phenyl)-phenyl-methanone

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Technology Process of (3-{6-benzyloxy-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-8-ylamino}-phenyl)-phenyl-methanone

There total 5 articles about (3-{6-benzyloxy-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-8-ylamino}-phenyl)-phenyl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 2835-78-1
3-amino benzophenone

: 479408-23-6
O⁶-benzyl-8-bromo-3′,5′-O-bis(tert-butyldimethylsilyl)-N²-dimethoxytrityl-2′-deoxyguanosine

: 479408-29-2
(3-{6-benzyloxy-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-8-ylamino}-phenyl)-phenyl-methanone

Guidance literature:: With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In toluene; at 100 ℃;
DOI:10.1021/ol026474f

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 479408-29-2
(3-{6-benzyloxy-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-8-ylamino}-phenyl)-phenyl-methanone

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / imidazole / dimethylformamide; tetrahydrofuran / 5 h / 20 °C

2: 78 percent / triphenylphosphine; diisopropyl azodicarboxylate / dioxane / 5 h / 20 °C

3: 94 percent / pyridine / 20 °C

4: 61 percent / sodium tert-butoxide; rac-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl / Pd₂(dba)3 / toluene / 100 °C

With pyridine; 1H-imidazole; di-isopropyl azodicarboxylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triphenylphosphine; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; toluene; 4: Buchwald-Hartwig coupling;
DOI:10.1021/ol026474f

Reference yield:

: 13389-03-2
8-bromo-2'-deoxyguanosine

: 479408-29-2
(3-{6-benzyloxy-2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-8-ylamino}-phenyl)-phenyl-methanone

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / imidazole / dimethylformamide; tetrahydrofuran / 5 h / 20 °C

2: 78 percent / triphenylphosphine; diisopropyl azodicarboxylate / dioxane / 5 h / 20 °C

3: 94 percent / pyridine / 20 °C

4: 61 percent / sodium tert-butoxide; rac-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl / Pd₂(dba)3 / toluene / 100 °C

With pyridine; 1H-imidazole; di-isopropyl azodicarboxylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triphenylphosphine; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; toluene; 4: Buchwald-Hartwig coupling;
DOI:10.1021/ol026474f