5-[3-(5-Oxo-4H-[1,2,4]oxadiazol-3-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepin-2,4(3H,5H)-dione

Base Information

Chemical Name:5-[3-(5-Oxo-4H-[1,2,4]oxadiazol-3-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepin-2,4(3H,5H)-dione
CAS No.:1239578-78-9
Molecular Formula:C₂₁H₁₄N₄O₄
Molecular Weight:386.367
Hs Code.:

Synonyms:5-[3-(5-Oxo-4H-[1,2,4]oxadiazol-3-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepin-2,4(3H,5H)-dione

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Chemical Property of 5-[3-(5-Oxo-4H-[1,2,4]oxadiazol-3-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepin-2,4(3H,5H)-dione

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Technology Process of 5-[3-(5-Oxo-4H-[1,2,4]oxadiazol-3-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepin-2,4(3H,5H)-dione

There total 6 articles about 5-[3-(5-Oxo-4H-[1,2,4]oxadiazol-3-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepin-2,4(3H,5H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1239578-87-0
5-[3-(N-hydroxyamidino)phenyl]-1H-naphtho[1,2-b][1,4]diazepin-2,4(3H,5H)-dione

: 1885-14-9
phenyl chloroformate

: 1239578-78-9
5-[3-(5-Oxo-4H-[1,2,4]oxadiazol-3-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepin-2,4(3H,5H)-dione

Guidance literature:: 5-[3-(N-hydroxyamidino)phenyl]-1H-naphtho[1,2-b][1,4]diazepin-2,4(3H,5H)-dione; phenyl chloroformate; With pyridine; In dichloromethane; at 20 ℃; for 1.5h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; at 20 ℃; for 0.25h;

Reference yield:

: 606-57-5
1-nitro-2-naphthylamine

: 1239578-78-9
5-[3-(5-Oxo-4H-[1,2,4]oxadiazol-3-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepin-2,4(3H,5H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene / 16 h / 110 °C

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 4 h / 20 °C

3.1: toluene / 0.5 h / 80 - 110 °C / Cooling with ice

4.1: hydroxylamine hydrochloride; triethylamine / tetrahydrofuran; methanol / 2 h / Reflux

5.1: pyridine / dichloromethane / 1.5 h / 20 °C

5.2: 0.25 h / 20 °C

With pyridine; hydroxylamine hydrochloride; hydrogen; caesium carbonate; triethylamine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; methanol; dichloromethane; toluene;

Reference yield:

: 1238331-97-9
3-(1-nitro-2-naphthylamino)benzonitrile

: 1239578-78-9
5-[3-(5-Oxo-4H-[1,2,4]oxadiazol-3-yl)phenyl]-1H-naphtho[1,2-b][1,4]diazepin-2,4(3H,5H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 4 h / 20 °C

2.1: toluene / 0.5 h / 80 - 110 °C / Cooling with ice

3.1: hydroxylamine hydrochloride; triethylamine / tetrahydrofuran; methanol / 2 h / Reflux

4.1: pyridine / dichloromethane / 1.5 h / 20 °C

4.2: 0.25 h / 20 °C

With pyridine; hydroxylamine hydrochloride; hydrogen; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; toluene;