(S)-tert-butyl 5-(4-(dimethylamino)phenyl)-3-oxo-1-phenylpent-4-yn-2-ylcarbamate

Base Information

Chemical Name:(S)-tert-butyl 5-(4-(dimethylamino)phenyl)-3-oxo-1-phenylpent-4-yn-2-ylcarbamate
CAS No.:1414917-90-0
Molecular Formula:C₂₄H₂₈N₂O₃
Molecular Weight:392.498
Hs Code.:

Synonyms:(S)-tert-butyl 5-(4-(dimethylamino)phenyl)-3-oxo-1-phenylpent-4-yn-2-ylcarbamate

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Chemical Property of (S)-tert-butyl 5-(4-(dimethylamino)phenyl)-3-oxo-1-phenylpent-4-yn-2-ylcarbamate

Chemical Property:

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Technology Process of (S)-tert-butyl 5-(4-(dimethylamino)phenyl)-3-oxo-1-phenylpent-4-yn-2-ylcarbamate

There total 1 articles about (S)-tert-butyl 5-(4-(dimethylamino)phenyl)-3-oxo-1-phenylpent-4-yn-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 17573-94-3,752235-18-0
4-ethynyl-N,N-dimethylaniline

: 142955-51-9
N-butoxycarbonyl-L-phenylalanine anhydride

: 1414917-90-0
(S)-tert-butyl 5-(4-(dimethylamino)phenyl)-3-oxo-1-phenylpent-4-yn-2-ylcarbamate

Guidance literature:: 4-ethynyl-N,N-dimethylaniline; With n-butyllithium; lithium bromide; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

N-butoxycarbonyl-L-phenylalanine anhydride; In tetrahydrofuran; hexane; at -78 ℃; for 4h; Inert atmosphere;
DOI:10.1039/c2ob26427g

Reference yield:

: 1414917-90-0
(S)-tert-butyl 5-(4-(dimethylamino)phenyl)-3-oxo-1-phenylpent-4-yn-2-ylcarbamate

: 1414917-97-7
C₂₄H₂₇IN₂O₃

: C₂₄H₂₇IN₂O₃

Guidance literature:: With iodine; sodium hydrogencarbonate; In acetonitrile; at 20 ℃; for 2h; Overall yield = 94 %; Overall yield = 27.4 mg;
DOI:10.1039/c2ob26427g

Reference yield:

: 1414917-90-0
(S)-tert-butyl 5-(4-(dimethylamino)phenyl)-3-oxo-1-phenylpent-4-yn-2-ylcarbamate

: 1422143-24-5
2-benzyl-5-(4-dimethylaminophenyl)-3-oxo-2,3-dihydropyrrole-1-carboxylic acid tert-butyl ester

: 2-benzyl-5-(4-dimethylaminophenyl)-3-oxo-2,3-dihydropyrrole-1-carboxylic acid tert-butyl ester

Guidance literature:: With potassium carbonate; platinum(II) chloride; at 70 ℃; for 0.5h; Overall yield = 90 %; Overall yield = 17.7 mg; Sealed tube; Microwave irradiation; Green chemistry;
DOI:10.1021/jo302474r