Propargyl-PEG5-CH2CO2H

Base Information

• Chemical Name: Propargyl-PEG5-CH2CO2H
• CAS No.: 1429934-37-1
• Molecular Formula: C₁₃H₂₂O₇
• Molecular Weight: 290.313
• Mol file: 1429934-37-1.mol

Synonyms:3,6,9,12,15-pentaoxaoctadec-17-ynoic acid

Chemical Property of Propargyl-PEG5-CH2CO2H

Chemical Property:

Purity/Quality:

99.3% ^*data from raw suppliers

Propargyl-PEG5-CH2CO2H 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Propargyl-PEG5-CH2CO2H is an alkyne linker with a carboxylic acid. The carboxylic acid can react with primary amines to form stable amide bonds; activator (e.g. EDC, or HATU) is needed. The alkyne group can participate in copper catalyzed azide-alkyne Click Chemistry to form stable triazole linkage.

Technology Process of Propargyl-PEG5-CH2CO2H

There total 6 articles about Propargyl-PEG5-CH2CO2H which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl 3,6,9,12,15-pentaoxaoctadec-17-ynoate → 3,6,9,12,15-pentaoxaoctadec-17-ynoic acid (1429934-37-1)

Guidance literature:

With sodium hydroxide; In methanol; water;

DOI:10.1002/chem.201700607

Reference yield:

C14H24O7 → 3,6,9,12,15-pentaoxaoctadec-17-ynoic acid (1429934-37-1)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 2h;

Reference yield:

Tetraethylene glycol (112-60-7) → 3,6,9,12,15-pentaoxaoctadec-17-ynoic acid (1429934-37-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / tetrahydrofuran

2: sodium hydride / tetrahydrofuran

With potassium tert-butylate; sodium hydride; In tetrahydrofuran;

upstream raw materials:

Tetraethylene glycol

ethyl bromoacetate

3,6,9,12-tetraoxapentadec-14-yn-1-ol