3-methyl-5-(4-chlorophenoxy)-1-(4-methylphenyl)-1H-pyrazole-4-carbaldehyde

Base Information

• Chemical Name: 3-methyl-5-(4-chlorophenoxy)-1-(4-methylphenyl)-1H-pyrazole-4-carbaldehyde
• CAS No.: 1333899-75-4
• Molecular Formula: C₁₈H₁₅ClN₂O₂
• Molecular Weight: 326.782

Synonyms:3-methyl-5-(4-chlorophenoxy)-1-(4-methylphenyl)-1H-pyrazole-4-carbaldehyde

Chemical Property of 3-methyl-5-(4-chlorophenoxy)-1-(4-methylphenyl)-1H-pyrazole-4-carbaldehyde

Chemical Property:

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Technology Process of 3-methyl-5-(4-chlorophenoxy)-1-(4-methylphenyl)-1H-pyrazole-4-carbaldehyde

There total 2 articles about 3-methyl-5-(4-chlorophenoxy)-1-(4-methylphenyl)-1H-pyrazole-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

5-chloro-3-methyl-1-(p-tolyl)-1H-pyrazole-4-carbaldehyde (350997-70-5) + 4-chloro-phenol (106-48-9,82344-39-6) → 3-methyl-5-(4-chlorophenoxy)-1-(4-methylphenyl)-1H-pyrazole-4-carbaldehyde (1333899-75-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 4h; Reflux;

DOI:10.2478/s11532-011-0041-7

Reference yield:

3-methyl-1-(4-methylphenyl)-2-pyrazolin-5-one (86-92-0) → 3-methyl-5-(4-chlorophenoxy)-1-(4-methylphenyl)-1H-pyrazole-4-carbaldehyde (1333899-75-4)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate

2: potassium carbonate / N,N-dimethyl-formamide / 4 h / Reflux

With potassium carbonate; trichlorophosphate; In N,N-dimethyl-formamide; 1: Vilsmeier-Haack reaction;

DOI:10.2478/s11532-011-0041-7

Reference yield: 75.0%

2-(2-methyl-5-nitro-1H-imidazol-1-yl)acetohydrazide (126359-46-4) + 3-methyl-5-(4-chlorophenoxy)-1-(4-methylphenyl)-1H-pyrazole-4-carbaldehyde (1333899-75-4) → (E)-N'-((5-(4-chlorophenoxy)-3-methyl-1-p-tolyl-1H-pyrazol-4-yl)methylene)-2-(2-methyl-5-nitro-1H-imidazol-1-yl)acetohydrazide

Guidance literature:

With nickel(II) nitrate hexahydrate; In ethanol; at 20 ℃;

DOI:10.1007/s11164-015-2018-1

upstream raw materials:

5-chloro-3-methyl-1-(p-tolyl)-1H-pyrazole-4-carbaldehyde

4-chloro-phenol

3-methyl-1-(4-methylphenyl)-2-pyrazolin-5-one

Downstream raw materials:

2-amino-4-(5-(4-chlorophenoxy)-3-methyl-1-(4-methylphenyl)-1H-pyrazol-4-yl)-5-oxo-4,5-dihydropyrano[3,2-c]chromene-3-carbonitrile

2-amino-4-(5-(4-chlorophenoxy)-3-methyl-1-(4-methylphenyl)-1H-pyrazol-4-yl)-9-methyl-5-oxo-4,5-dihydropyrano[3,2-c]chromene-3-carbonitrile

C₂₇H₂₃ClN₄O₃

C₂₉H₂₇ClN₄O₃

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