350997-70-5Relevant articles and documents
Synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives: Assessment of their antimicrobial, antituberculosis and antioxidant activity
Sangani, Chetan B.,Makwana, Jigar A.,Duan, Yong-Tao,Thumar, Nilesh J.,Zhao, Meng-Yue,Patel, Yogesh S.,Zhu, Hai-Liang
, p. 2101 - 2117 (2016)
A new series of pyrazolo[1,2-b]phthalazine derivatives (4a-p) bearing the 5-aryloxypyrazole nucleus was synthesized by one-pot, three-component, base-catalyzed cyclo condensation reaction of 3-methyl-5-aryloxy-1-aryl-1H-pyrazole-4-carbaldehyde (1a-d), mal
A novel synthetic method of organoselenum compounds
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Paragraph 0122-0126; 0127-0132; 0133-0138, (2021/09/07)
The present application can synthesize a selenopyrano pyrazolone derivative, one of an organic selenium compound, in a simple and excellent yield. Provided is a synthesis method of an organic selenium compound which is eco-friendly at low temperature and
Design, synthesis and biological evaluation of novel pyrazole sulfonamide derivatives as potential AHAS inhibitors
Lv, Xian-Hai,Ren, Zi-Li,Liu, Hao,Li, Hai-Dong,Li, Qing-Shan,Wang, Li,Zhang, Li-Song,Yao, Xiao-Kang,Cao, Hai-Qun
, p. 358 - 362 (2018/04/09)
Acetohydroxy acid synthase (AHAS; EC 2.2.1.6, also referred to as acetolactate synthase, ALS) has been considered as an attractive target for the design of herbicides. In this work, an optimized pyrazole sulfonamide base scaffold was designed and introduced to derive novel potential AHAS inhibitors by introducing a pyrazole ring in flucarbazone. The results of in vivo herbicidal activity evaluation indicates compound 3b has the most potent activity with rape root length inhibition values of 81percent at 100 mg/L, and exhibited the best inhibitory ability against Arabidopsis thaliana AHAS. With molecular docking, compound 3b insert into Arabidopsis thaliana AHAS stably by an H-bond with Arg377 and cation-p interactions with Arg377, Trp574, Tyr579. This study suggests that compound 3b may serve as a potential AHAS inhibitor which can be used as a novel herbicides and provides valuable clues for the further design and optimization of AHAS inhibitors.