methyl 7,8-dimethoxy-1-(4,5-dimethoxy-2-hydroxyphenyl)-<1>-benzopyrano<3,4-b>pyrrol-4(3H)-one-2-carboxylate

Base Information

Chemical Name:methyl 7,8-dimethoxy-1-(4,5-dimethoxy-2-hydroxyphenyl)-<1>-benzopyrano<3,4-b>pyrrol-4(3H)-one-2-carboxylate
CAS No.:220230-73-9
Molecular Formula:C₂₃H₂₁NO₉
Molecular Weight:455.421
Hs Code.:

Synonyms:methyl 7,8-dimethoxy-1-(4,5-dimethoxy-2-hydroxyphenyl)-<1>-benzopyrano<3,4-b>pyrrol-4(3H)-one-2-carboxylate

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Chemical Property of methyl 7,8-dimethoxy-1-(4,5-dimethoxy-2-hydroxyphenyl)-<1>-benzopyrano<3,4-b>pyrrol-4(3H)-one-2-carboxylate

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Technology Process of methyl 7,8-dimethoxy-1-(4,5-dimethoxy-2-hydroxyphenyl)-<1>-benzopyrano<3,4-b>pyrrol-4(3H)-one-2-carboxylate

There total 8 articles about methyl 7,8-dimethoxy-1-(4,5-dimethoxy-2-hydroxyphenyl)-<1>-benzopyrano<3,4-b>pyrrol-4(3H)-one-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 220230-71-7
dimethyl 3,4-bis(4,5-dimethoxy-2-(methoxymethoxy)phenyl)pyrrole-2,5-dicarboxylate

: 220230-73-9
methyl 7,8-dimethoxy-1-(4,5-dimethoxy-2-hydroxyphenyl)-<1>-benzopyrano<3,4-b>pyrrol-4(3H)-one-2-carboxylate

: dimethyl 3,4-bis(2-hydroxy-4,5-dimethoxyphenyl)pyrrole-2,5-dicarboxylate

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 25 ℃; for 2h; Title compound not separated from byproducts;
DOI:10.1021/ja982078+

Reference yield:

: 5392-10-9
2-bromo-4,5-dimethoxybenzaldehyde

: 220230-73-9
methyl 7,8-dimethoxy-1-(4,5-dimethoxy-2-hydroxyphenyl)-<1>-benzopyrano<3,4-b>pyrrol-4(3H)-one-2-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / mCPBA

2: 72 percent / MeOH, NaOCH₃

3: 77 percent / NaH

4: 1.) Pd(PPh₃)4 / 1.) toluene, 15 min, 2.) toluene, 100 deg C, 4 h

5: 87 percent / toluene / 61 h / 105 °C

6: 63 percent / Zn, HOAC / 16.5 h / 25 °C

7: 1.) 3 M aq. HCl, 2.) SiO₂ / 1.) EtOAc, 25 deg C, 2 h, 2.) acetone, CH₂Cl₂

With hydrogenchloride; methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; silica gel; sodium hydride; acetic acid; 3-chloro-benzenecarboperoxoic acid; zinc; In toluene;
DOI:10.1021/ja982078+

Reference yield:

: 129103-69-1
2-bromo-4,5-dimethoxyphenol

: 220230-73-9
methyl 7,8-dimethoxy-1-(4,5-dimethoxy-2-hydroxyphenyl)-<1>-benzopyrano<3,4-b>pyrrol-4(3H)-one-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / NaH

2: 1.) Pd(PPh₃)4 / 1.) toluene, 15 min, 2.) toluene, 100 deg C, 4 h

3: 87 percent / toluene / 61 h / 105 °C

4: 63 percent / Zn, HOAC / 16.5 h / 25 °C

5: 1.) 3 M aq. HCl, 2.) SiO₂ / 1.) EtOAc, 25 deg C, 2 h, 2.) acetone, CH₂Cl₂

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; silica gel; sodium hydride; acetic acid; zinc; In toluene;
DOI:10.1021/ja982078+