Technology Process of ethyl 6-acetylbenzothiophene-2-carboxylate
There total 4 articles about ethyl 6-acetylbenzothiophene-2-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl 6-{[methoxy(methyl)amino]carbonyl}-1-benzothiophene-2-carboxylate; methyllithium;
In
tetrahydrofuran; diethyl ether;
at -78 ℃;
for 1h;
With
ammonium chloride;
In
tetrahydrofuran; diethyl ether;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: pyridine; lithium iodide / 3 h / Heating / reflux
1.2: 20 °C
2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 1 h / 0 °C
3.1: tetrahydrofuran; diethyl ether / 1 h / -78 °C
With
pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium iodide;
In
tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 50 °C
2.1: pyridine; lithium iodide / 3 h / Heating / reflux
2.2: 20 °C
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 1 h / 0 °C
4.1: tetrahydrofuran; diethyl ether / 1 h / -78 °C
With
pyridine; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium iodide;
In
tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;