ethyl 6-{1-[(4-methoxybenzyl)amino]ethyl}-1-benzothiophene-2-carboxylate

Base Information

Chemical Name:ethyl 6-{1-[(4-methoxybenzyl)amino]ethyl}-1-benzothiophene-2-carboxylate
CAS No.:913738-88-2
Molecular Formula:C₂₁H₂₃NO₃S
Molecular Weight:369.485
Hs Code.:

Synonyms:ethyl 6-{1-[(4-methoxybenzyl)amino]ethyl}-1-benzothiophene-2-carboxylate

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Chemical Property of ethyl 6-{1-[(4-methoxybenzyl)amino]ethyl}-1-benzothiophene-2-carboxylate

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Technology Process of ethyl 6-{1-[(4-methoxybenzyl)amino]ethyl}-1-benzothiophene-2-carboxylate

There total 5 articles about ethyl 6-{1-[(4-methoxybenzyl)amino]ethyl}-1-benzothiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 913738-62-2
ethyl 6-acetyl-1-benzothiophene-2-carboxylate

: 2393-23-9
4-methoxy-benzylamine

: 913738-88-2
ethyl 6-{1-[(4-methoxybenzyl)amino]ethyl}-1-benzothiophene-2-carboxylate

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 120h;

Reference yield:

: 850074-42-9
2-ethyl 6-methyl benzo[b]thiophene-2,6-dicarboxylate

: 913738-88-2
ethyl 6-{1-[(4-methoxybenzyl)amino]ethyl}-1-benzothiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine; lithium iodide / 3 h / Heating / reflux

1.2: 20 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 1 h / 0 °C

3.1: tetrahydrofuran; diethyl ether / 1 h / -78 °C

4.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 120 h / 20 °C

With pyridine; sodium tris(acetoxy)borohydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium iodide; In tetrahydrofuran; diethyl ether; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 153813-69-5
methyl 4-formyl-3-nitrobenzoate

: 913738-88-2
ethyl 6-{1-[(4-methoxybenzyl)amino]ethyl}-1-benzothiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 50 °C

2.1: pyridine; lithium iodide / 3 h / Heating / reflux

2.2: 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 1 h / 0 °C

4.1: tetrahydrofuran; diethyl ether / 1 h / -78 °C

5.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 120 h / 20 °C

With pyridine; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium iodide; In tetrahydrofuran; diethyl ether; 1,2-dichloro-ethane; N,N-dimethyl-formamide;