tert-butyl 4-(3-(2-(tert-butoxycarbonylamino)-5-fluorophenylcarbamoyl)quinolin-7-yl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(3-(2-(tert-butoxycarbonylamino)-5-fluorophenylcarbamoyl)quinolin-7-yl)piperazine-1-carboxylate
CAS No.:1621399-72-1
Molecular Formula:C₃₀H₃₆FN₅O₅
Molecular Weight:565.645
Hs Code.:

Synonyms:tert-butyl 4-(3-(2-(tert-butoxycarbonylamino)-5-fluorophenylcarbamoyl)quinolin-7-yl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(3-(2-(tert-butoxycarbonylamino)-5-fluorophenylcarbamoyl)quinolin-7-yl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(3-(2-(tert-butoxycarbonylamino)-5-fluorophenylcarbamoyl)quinolin-7-yl)piperazine-1-carboxylate

There total 4 articles about tert-butyl 4-(3-(2-(tert-butoxycarbonylamino)-5-fluorophenylcarbamoyl)quinolin-7-yl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 579474-47-8
(2-amino-4-fluoro-phenyl)carbamic acid tert-butyl ester

: 1609391-35-6
7-(4-(tert-butoxycarbonyl)-piperazin-1-yl)quinoline-3-carboxylic acid

: 1621399-72-1
tert-butyl 4-(3-(2-(tert-butoxycarbonylamino)-5-fluorophenylcarbamoyl)quinolin-7-yl)piperazine-1-carboxylate

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 55 ℃;

Reference yield:

: ethyl 7-(4-(tert-butoxycarbonyl)piperazin-1-yl)quinoline-3-carboxylate

: 1621399-72-1
tert-butyl 4-(3-(2-(tert-butoxycarbonylamino)-5-fluorophenylcarbamoyl)quinolin-7-yl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; sodium hydroxide / tetrahydrofuran / 4 h / 70 °C

2: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 55 °C

With methanol; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1226762-74-8
7-bromoquinoline-3-carboxylic acid ethyl ester

: 1621399-72-1
tert-butyl 4-(3-(2-(tert-butoxycarbonylamino)-5-fluorophenylcarbamoyl)quinolin-7-yl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos; caesium carbonate / toluene / 1.67 h / 80 - 145 °C / Microwave irradiation

2: methanol; sodium hydroxide / tetrahydrofuran / 4 h / 70 °C

3: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 55 °C

With methanol; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1-hydroxy-7-aza-benzotriazole; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; ruphos; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;