1226762-74-8Relevant articles and documents
Selective reductive annulation reaction for direct synthesis of functionalized quinolines by a cobalt nanocatalyst
Xie, Rong,Lu, Guang-Peng,Jiang, Huan-Feng,Zhang, Min
, p. 239 - 243 (2020/02/15)
Due to the extensive applications of quinolines, the search for selective construction of such products has long been an attractive subject in scientific community. Herein, by developing a new N-doped ZrO2@C supported cobalt nanomaterial, it has been successfully applied as an efficient catalyst for the reductive annulation of 2-nitroaryl carbonyls with alkynoates and alkynones. The catalytic transformation allows synthesizing a wide array of funcitonalized quinolines with the merits of broad substrate scope, good functional group tolerance, excellent hydrogen transfer selectivity, reusable earth-abundant metal catalyst, and operational simplicity. The developed chemistry paves the ways for further design of hydrogen transfer-mediated coupling reactions by developing heterogeneous catalysts with suitable supports.
OXADIAZOLE INHIBITORS OF HIPK2 FOR TREATING KIDNEY FIBROSIS
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Paragraph 0051, (2018/07/31)
Compounds that are selective inhibitors of Smad3 activation are disclosed. The compounds have the structure (I) in which Z is an oxadiazole. The compounds disclosed are useful in treatment of fibrotic disease, particularly renal fibrosis, and similar dise
FATTY ACID SYNTHASE INHIBITORS
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Page/Page column 58; 59, (2014/01/07)
Disclosed are compounds having Formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, Y, m, and n are defined herein and methods of using the same.
