7-(benzyloxy)-2-(3,4-dibenzyloxyphenyl)-5-hydroxy-4-oxo-4H-chromen-3-yl 3-(benzyloxy)-4-(dibenzylamino)benzoate

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Chemical Name:7-(benzyloxy)-2-(3,4-dibenzyloxyphenyl)-5-hydroxy-4-oxo-4H-chromen-3-yl 3-(benzyloxy)-4-(dibenzylamino)benzoate
CAS No.:1355333-60-6
Molecular Formula:C₆₄H₅₁NO₉
Molecular Weight:978.11
Hs Code.:

Synonyms:7-(benzyloxy)-2-(3,4-dibenzyloxyphenyl)-5-hydroxy-4-oxo-4H-chromen-3-yl 3-(benzyloxy)-4-(dibenzylamino)benzoate

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Chemical Property of 7-(benzyloxy)-2-(3,4-dibenzyloxyphenyl)-5-hydroxy-4-oxo-4H-chromen-3-yl 3-(benzyloxy)-4-(dibenzylamino)benzoate

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Technology Process of 7-(benzyloxy)-2-(3,4-dibenzyloxyphenyl)-5-hydroxy-4-oxo-4H-chromen-3-yl 3-(benzyloxy)-4-(dibenzylamino)benzoate

There total 3 articles about 7-(benzyloxy)-2-(3,4-dibenzyloxyphenyl)-5-hydroxy-4-oxo-4H-chromen-3-yl 3-(benzyloxy)-4-(dibenzylamino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 183067-65-4
7-(benzyloxy)-2-(3,4-bis(benzyloxy)phenyl)-3,5-dihydroxy-4H-chromen-4-one

: 1355333-56-0
3-(benzyloxy)-4-(dibenzylamino)benzoic acid

: 1355333-60-6
7-(benzyloxy)-2-(3,4-dibenzyloxyphenyl)-5-hydroxy-4-oxo-4H-chromen-3-yl 3-(benzyloxy)-4-(dibenzylamino)benzoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 25 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.10.119

Reference yield:

: 1355333-67-3
benzyl 3-(benzyloxy)-4-(dibenzylamino)benzoate

: 1355333-60-6
7-(benzyloxy)-2-(3,4-dibenzyloxyphenyl)-5-hydroxy-4-oxo-4H-chromen-3-yl 3-(benzyloxy)-4-(dibenzylamino)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / 1,4-dioxane; methanol; water / 3 h / Reflux

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 25 °C / Inert atmosphere

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2011.10.119

Reference yield:

: 2374-03-0
4-aminosalicylic acid

: 1355333-60-6
7-(benzyloxy)-2-(3,4-dibenzyloxyphenyl)-5-hydroxy-4-oxo-4H-chromen-3-yl 3-(benzyloxy)-4-(dibenzylamino)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 25 °C / Inert atmosphere

1.2: 16 h / 80 °C / Inert atmosphere

2.1: sodium hydroxide / 1,4-dioxane; methanol; water / 3 h / Reflux

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 25 °C / Inert atmosphere

With dmap; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.10.119