183067-65-4Relevant articles and documents
Synthesis of montbretin A analogues yields potent competitive inhibitors of human pancreatic α-amylase
Tysoe, Christina R.,Caner, Sami,Calvert, Matthew B.,Win-Mason, Anna,Brayer, Gary D.,Withers, Stephen G.
, p. 11073 - 11077 (2019)
Simplified analogues of the potent human amylase inhibitor montbretin A were synthesised and shown to bind tightly, KI = 60 and 70 nM, with improved specificity over medically relevant glycosidases, making them promising candidates for controlling blood glucose. Crystallographic analysis confirmed similar binding modes and identified new active site interactions.
Synthesis, characterization and antioxidant activity of quercetin derivatives
Sun, Lei,Lu, Bo,Liu, Yandan,Wang, Qian,Li, Gao,Zhao, Longxuan,Zhao, Chunhui
, p. 2944 - 2953 (2021/08/25)
A series of quercetin derivatives were synthesized via Williamson etherification, Steglich esterification or Koenigs–Knorr glycosylation reaction at 3 and 7 position hydroxyl groups selectively. The structures of the synthesized compounds were characteriz
The first synthesis of 3-O-methylcyanidin and the effect of 3-O-substitution on stability under acidic conditions
El-Meligy, Asmaa B.,Ishihara, Takehiro,Oyama, Kin-Ichi,El-Nahas, Ahmed M.,Yoshida, Kumi
, p. 946 - 959 (2019/04/26)
The simplest and most common anthocyanin in nature is 3-O-glucosylcyanidin (1), and 3-O-glucosylation is believed to stabilize the chromophore. To clarify the effect of the glucose residue we compared the stability of 1 with its aglycone, cyanidin (2), an