methanesulfonic acid 3-[7-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-2-oxo-butyl ester

Base Information

Chemical Name:methanesulfonic acid 3-[7-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-2-oxo-butyl ester
CAS No.:436097-24-4
Molecular Formula:C₂₁H₂₃NO₇S₂
Molecular Weight:465.548
Hs Code.:

methanesulfonic acid 3-[7-methoxy-1-(toluene-4-sulfonyl)-1<i>H</i>-indol-4-yl]-2-oxo-butyl ester

Synonyms:methanesulfonic acid 3-[7-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-2-oxo-butyl ester

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Chemical Property of methanesulfonic acid 3-[7-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-2-oxo-butyl ester

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Technology Process of methanesulfonic acid 3-[7-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-2-oxo-butyl ester

There total 11 articles about methanesulfonic acid 3-[7-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-2-oxo-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 124-63-0
methanesulfonyl chloride

: 436093-85-5
1-hydroxy-3-[7-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-butan-2-one

: 436097-24-4
methanesulfonic acid 3-[7-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-2-oxo-butyl ester

Guidance literature:: With triethylamine;
DOI:10.1016/S0040-4039(01)02331-0

Reference yield:

: 4920-77-8
3-methyl-2-nitrophenol

: 436097-24-4
methanesulfonic acid 3-[7-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-2-oxo-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 98 percent / Br₂ / acetic acid / 6 h

2: 100 percent / K₂CO₃ / Heating

3: pyrrolidine / dimethylformamide / 14 h / 110 °C

4: NH₂NH₂*H₂O; Raney-Ni / methanol; tetrahydrofuran

5: 82 percent / nBuLi / tetrahydrofuran

6: 92 percent / nBuLi; BF₃*Et₂O; CuCN / tetrahydrofuran / -78 °C

7: 98 percent / nBu₄NF

8: 89 percent / NaH

9: 87 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -40 - 20 °C

10: 96 percent / Et₃N

With pyrrolidine; n-butyllithium; oxalyl dichloride; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; bromine; nickel; sodium hydride; potassium carbonate; hydrazine hydrate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; 3: Batcho-Leimgruber indole synthesis / 9: Swern-oxidation;
DOI:10.1016/S0040-4039(01)02331-0

Reference yield:

: 85598-12-5
4-bromo-3-methyl-2-nitro-phenol

: 436097-24-4
methanesulfonic acid 3-[7-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-2-oxo-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 100 percent / K₂CO₃ / Heating

2: pyrrolidine / dimethylformamide / 14 h / 110 °C

3: NH₂NH₂*H₂O; Raney-Ni / methanol; tetrahydrofuran

4: 82 percent / nBuLi / tetrahydrofuran

5: 92 percent / nBuLi; BF₃*Et₂O; CuCN / tetrahydrofuran / -78 °C

6: 98 percent / nBu₄NF

7: 89 percent / NaH

8: 87 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -40 - 20 °C

9: 96 percent / Et₃N

With pyrrolidine; n-butyllithium; oxalyl dichloride; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; nickel; sodium hydride; potassium carbonate; hydrazine hydrate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 2: Batcho-Leimgruber indole synthesis / 8: Swern-oxidation;
DOI:10.1016/S0040-4039(01)02331-0