N,N,4-Trimethyl-1-phenyl-4H-(1,2,4)triazolo(4,3-a)(1,5)benzodiazepin-5-amine

Base Information

Chemical Name:N,N,4-Trimethyl-1-phenyl-4H-(1,2,4)triazolo(4,3-a)(1,5)benzodiazepin-5-amine
CAS No.:133118-18-0
Molecular Formula:C₁₉H₁₉N₅
Molecular Weight:317.393
Hs Code.:
DSSTox Substance ID:DTXSID50927950
Nikkaji Number:J358.152G

Synonyms:BRN 4204004;N,N,4-Trimethyl-1-phenyl-4H-(1,2,4)triazolo(4,3-a)(1,5)benzodiazepin-5-amine;4H-(1,2,4)Triazolo(4,3-a)(1,5)benzodiazepin-5-amine, 1-phenyl-N,N,4-trimethyl-;133118-18-0;N,N,4-trimethyl-1-phenyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5-amine;DTXSID50927950;LS-156301;1-Phenyl-4-methyl-5-(dimethylamino)-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine

Suppliers and Price of N,N,4-Trimethyl-1-phenyl-4H-(1,2,4)triazolo(4,3-a)(1,5)benzodiazepin-5-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N,N,4-Trimethyl-1-phenyl-4H-(1,2,4)triazolo(4,3-a)(1,5)benzodiazepin-5-amine

Chemical Property:

Vapor Pressure:2.1E-11mmHg at 25°C
Boiling Point:532.1°C at 760 mmHg
Flash Point:275.6°C
Density:1.23g/cm³
XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:317.16404563
Heavy Atom Count:24
Complexity:470

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1C2=NN=C(N2C3=CC=CC=C3N=C1N(C)C)C4=CC=CC=C4

Technology Process of N,N,4-Trimethyl-1-phenyl-4H-(1,2,4)triazolo(4,3-a)(1,5)benzodiazepin-5-amine

There total 5 articles about N,N,4-Trimethyl-1-phenyl-4H-(1,2,4)triazolo(4,3-a)(1,5)benzodiazepin-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 133118-31-7
3-methyl-N,N-dimethyl-4-(methylthio)-3H-1,5-benzodiazepin-2-amine

: 613-94-5
benzoic acid hydrazide

: 133118-18-0
4-methyl-N,N-dimethyl-1-phenyl-4H-<1,2,4>triazolo<4,3-a><1,5>benzodiazepin-5-amine

: 133118-27-1
9-methyl-6,12-diphenyl-9H-bis<1,2,4>triazolo<4,3-a:3',4'-d><1,5>benzodiazepine

Guidance literature:: In various solvent(s); at 200 ℃; for 1h;
DOI:10.1016/0223-5234(90)90133-N

Reference yield:

: 20929-36-6
ethyl 2-methyl-N,N-dimethylmalonamate

: 133118-18-0
4-methyl-N,N-dimethyl-1-phenyl-4H-<1,2,4>triazolo<4,3-a><1,5>benzodiazepin-5-amine

Guidance literature:: Multi-step reaction with 4 steps

1: 9 percent / POCl₃ / 5 h / 120 °C

2: 91 percent / Lawesson's reagent / toluene / 0.5 h / 100 °C

3: 1.) NaH / 1.) THF, toluene, 50 deg C, 45 min, 2.) 50 deg C, 90 min

4: 34 percent / various solvent(s) / 1 h / 200 °C

With Lawessons reagent; sodium hydride; trichlorophosphate; In toluene;
DOI:10.1016/0223-5234(90)90133-N

Reference yield:

: 133118-33-9
4-(dimethylamino)-1,3-dihydro-3-methyl-2H-1,5-benzodiazepin-2-one

: 133118-18-0
4-methyl-N,N-dimethyl-1-phenyl-4H-<1,2,4>triazolo<4,3-a><1,5>benzodiazepin-5-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / Lawesson's reagent / toluene / 0.5 h / 100 °C

2: 1.) NaH / 1.) THF, toluene, 50 deg C, 45 min, 2.) 50 deg C, 90 min

3: 34 percent / various solvent(s) / 1 h / 200 °C

With Lawessons reagent; sodium hydride; In toluene;
DOI:10.1016/0223-5234(90)90133-N