tert-butyl (1S,2R)-1-(4-bromophenyl)-2-chloro-2-formylcyclopropanecarboxylate

Base Information

Chemical Name:tert-butyl (1S,2R)-1-(4-bromophenyl)-2-chloro-2-formylcyclopropanecarboxylate
CAS No.:1350707-53-7
Molecular Formula:C₁₅H₁₆BrClO₃
Molecular Weight:359.647
Hs Code.:

Synonyms:tert-butyl (1S,2R)-1-(4-bromophenyl)-2-chloro-2-formylcyclopropanecarboxylate

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Chemical Property of tert-butyl (1S,2R)-1-(4-bromophenyl)-2-chloro-2-formylcyclopropanecarboxylate

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Technology Process of tert-butyl (1S,2R)-1-(4-bromophenyl)-2-chloro-2-formylcyclopropanecarboxylate

There total 2 articles about tert-butyl (1S,2R)-1-(4-bromophenyl)-2-chloro-2-formylcyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 956905-15-0
tert-butyl α-(para-bromophenyl)diazoacetate

: 683-51-2
2-chloro-2-propenal

: 1350707-53-7
tert-butyl (1S,2R)-1-(4-bromophenyl)-2-chloro-2-formylcyclopropanecarboxylate

Guidance literature:: With CHF₃O₃S*C₃₁H₃₂BNO; In propiononitrile; at -25 ℃; for 5h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ja209270e

Reference yield:

: 33155-58-7
tert-butyl 2-(4-bromophenyl)acetate

: 1350707-53-7
tert-butyl (1S,2R)-1-(4-bromophenyl)-2-chloro-2-formylcyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0 - 20 °C / Inert atmosphere

2: CHF₃O₃S*C₃₁H₃₂BNO / propiononitrile / 5 h / -25 °C / Inert atmosphere

With CHF₃O₃S*C₃₁H₃₂BNO; 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; propiononitrile; 2: Michael-initiated cyclopropanation;
DOI:10.1021/ja209270e