(1R,2R,4R)-4-(4-bromo-2-trifluoromethylbenzenesulfonyl)-2-(3,3-difluoroazetidine-1-carbonyl)cyclopentanecarboxylic acid (1-cyanocyclopropyl)amide

Base Information

Chemical Name:(1R,2R,4R)-4-(4-bromo-2-trifluoromethylbenzenesulfonyl)-2-(3,3-difluoroazetidine-1-carbonyl)cyclopentanecarboxylic acid (1-cyanocyclopropyl)amide
CAS No.:1258445-91-8
Molecular Formula:C₂₁H₁₉BrF₅N₃O₄S
Molecular Weight:584.362
Hs Code.:

(1R,2R,4R)-4-(4-bromo-2-trifluoromethylbenzenesulfonyl)-2-(3,3-difluoroazetidine-1-carbonyl)cyclopentanecarboxylic acid (1-cyanocyclopropyl)amide

Synonyms:(1R,2R,4R)-4-(4-bromo-2-trifluoromethylbenzenesulfonyl)-2-(3,3-difluoroazetidine-1-carbonyl)cyclopentanecarboxylic acid (1-cyanocyclopropyl)amide

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Chemical Property of (1R,2R,4R)-4-(4-bromo-2-trifluoromethylbenzenesulfonyl)-2-(3,3-difluoroazetidine-1-carbonyl)cyclopentanecarboxylic acid (1-cyanocyclopropyl)amide

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Technology Process of (1R,2R,4R)-4-(4-bromo-2-trifluoromethylbenzenesulfonyl)-2-(3,3-difluoroazetidine-1-carbonyl)cyclopentanecarboxylic acid (1-cyanocyclopropyl)amide

There total 1 articles about (1R,2R,4R)-4-(4-bromo-2-trifluoromethylbenzenesulfonyl)-2-(3,3-difluoroazetidine-1-carbonyl)cyclopentanecarboxylic acid (1-cyanocyclopropyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1258452-01-5
(1R,2R,4S)-4-(4-Bromo-2-trifluoromethyl-benzenesulfonyl)-2-(3,3-difluoro-azetidine-1-carbonyl)-cyclopentanecarboxylic acid

: 127946-77-4
1-amino-1-cyclopropanecarbonitrile hydrochloride

: 1258445-91-8
(1R,2R,4R)-4-(4-bromo-2-trifluoromethylbenzenesulfonyl)-2-(3,3-difluoroazetidine-1-carbonyl)cyclopentanecarboxylic acid (1-cyanocyclopropyl)amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In acetonitrile; at 20 ℃; for 16h;

Reference yield: 34.0%

: 1258445-91-8
(1R,2R,4R)-4-(4-bromo-2-trifluoromethylbenzenesulfonyl)-2-(3,3-difluoroazetidine-1-carbonyl)cyclopentanecarboxylic acid (1-cyanocyclopropyl)amide

: 761446-44-0
1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 1258445-97-4
(1R,2R,4R)-2-(3,3-difluoroazetidine-1-carbonyl)-4-[4-(1-methyl-1H-pyrazol-4-yl)-2-trifluoromethylbenzenesulfonyl]cyclopentanecarboxylic acid (1-cyanocyclopropyl)amide

Guidance literature:: With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; N,N-dimethyl-formamide; at 80 ℃; for 2h; Inert atmosphere;