(3R,5S,6R)-2,3,5,6-Tetrahydro-3,5,6-triphenyl-1,4-oxazin-2-one

Base Information

• Chemical Name: (3R,5S,6R)-2,3,5,6-Tetrahydro-3,5,6-triphenyl-1,4-oxazin-2-one
• CAS No.: 144744-23-0
• Molecular Formula: C₂₂H₁₉NO₂
• Molecular Weight: 329.398
• Mol file: 144744-23-0.mol

Synonyms:(3R,5S,6R)-2,3,5,6-Tetrahydro-3,5,6-triphenyl-1,4-oxazin-2-one

Chemical Property of (3R,5S,6R)-2,3,5,6-Tetrahydro-3,5,6-triphenyl-1,4-oxazin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,5S,6R)-2,3,5,6-Tetrahydro-3,5,6-triphenyl-1,4-oxazin-2-one

There total 3 articles about (3R,5S,6R)-2,3,5,6-Tetrahydro-3,5,6-triphenyl-1,4-oxazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5r,6c-triphenyl-5,6-dihydro-[1,4]oxazin-2-one (22690-84-2) → 3r,5c,6c-triphenyl-morpholin-2-one (21451-92-3,127358-17-2,144744-23-0,144744-24-1)

Guidance literature:

With hydrogen; palladium on activated charcoal;

DOI:10.1016/S0040-4039(00)70750-7

Reference yield:

oxo-phenyl-acetic acid (1RS,2SR)-2-amino-1,2-diphenyl-ethyl ester; hydrochloride (21451-89-8) → 3r,5c,6c-triphenyl-morpholin-2-one (21451-92-3,127358-17-2,144744-23-0,144744-24-1)

Guidance literature:

Multi-step reaction with 2 steps

1: AgNO₃

2: H₂ / Pd-C

With hydrogen; silver nitrate; palladium on activated charcoal;

DOI:10.1016/S0040-4039(00)70750-7

Reference yield:

(1R,2S)-2-Amino-1,2-diphenylethanol (23190-16-1) → (3R,5S,6R)-2,3,5,6-Tetrahydro-3,5,6-triphenyl-1,4-oxazin-2-one (144744-23-0) + (3S,5S,6R)-2,3,5,6-Tetrahydro-3,5,6-triphenyl-1,4-oxazin-2-one (144744-24-1)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given;

DOI:10.1021/jo00051a044

upstream raw materials:

3,5r,6c-triphenyl-5,6-dihydro-[1,4]oxazin-2-one

oxo-phenyl-acetic acid (1RS,2SR)-2-amino-1,2-diphenyl-ethyl ester; hydrochloride

(1R,2S)-2-Amino-1,2-diphenylethanol

Downstream raw materials:

(S)-α-amino-α-phenylacetic acid hydrochloride

(R)-phenylglycine hydrochloride