2-amino-5-(4-(methylsulfonyl)phenyl)thiophene-3-carboxamide

Base Information

Chemical Name:2-amino-5-(4-(methylsulfonyl)phenyl)thiophene-3-carboxamide
CAS No.:1093878-22-8
Molecular Formula:C₁₂H₁₂N₂O₃S₂
Molecular Weight:296.371
Hs Code.:

Synonyms:2-amino-5-(4-(methylsulfonyl)phenyl)thiophene-3-carboxamide

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Chemical Property of 2-amino-5-(4-(methylsulfonyl)phenyl)thiophene-3-carboxamide

Chemical Property:

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Technology Process of 2-amino-5-(4-(methylsulfonyl)phenyl)thiophene-3-carboxamide

There total 5 articles about 2-amino-5-(4-(methylsulfonyl)phenyl)thiophene-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1093878-21-7
5-[4-(methylsulfonyl)phenyl]-2-nitrothiophene-3-carboxamide

: 1093878-22-8
2-amino-5-(4-(methylsulfonyl)phenyl)thiophene-3-carboxamide

Guidance literature:: With hydrogen; Pt/C doped with V; In methanol; at 20 ℃; for 1.5h;

Reference yield:

: 1201924-03-9
5-bromo-2-nitrothiophene-3-carbaldehyde oxime

: 1093878-22-8
2-amino-5-(4-(methylsulfonyl)phenyl)thiophene-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid; 1,2-bis-(diphenylphosphino)ethane / carbonyl bis(hydrido)tris(triphenylphosphine)ruthenium(II) / toluene / 24 h / 111 °C / Inert atmosphere

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 80 °C

3: hydrogen / Pt/C doped with V / methanol / 1.5 h / 20 °C

With hydrogen; sodium carbonate; toluene-4-sulfonic acid; 1,2-bis-(diphenylphosphino)ethane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbonyl bis(hydrido)tris(triphenylphosphine)ruthenium(II); In tetrahydrofuran; methanol; toluene;

Reference yield:

: 1093878-17-1
5-bromo-3-(dichloromethyl)-2-nitrothiophene

: 1093878-22-8
2-amino-5-(4-(methylsulfonyl)phenyl)thiophene-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: formic acid; zinc(II) chloride / Reflux

2: hydroxylamine hydrochloride; sodium acetate / ethanol / 20 °C

3: toluene-4-sulfonic acid; 1,2-bis-(diphenylphosphino)ethane / carbonyl bis(hydrido)tris(triphenylphosphine)ruthenium(II) / toluene / 24 h / 111 °C / Inert atmosphere

4: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 80 °C

5: hydrogen / Pt/C doped with V / methanol / 1.5 h / 20 °C

With formic acid; hydroxylamine hydrochloride; hydrogen; sodium acetate; sodium carbonate; toluene-4-sulfonic acid; 1,2-bis-(diphenylphosphino)ethane; zinc(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbonyl bis(hydrido)tris(triphenylphosphine)ruthenium(II); In tetrahydrofuran; methanol; ethanol; toluene;