5-Bromo-2-nitrothiophene-3-carbaldehyde

Base Information

Chemical Name:5-Bromo-2-nitrothiophene-3-carbaldehyde
CAS No.:1093878-18-2
Molecular Formula:C₅H₂BrNO₃S
Molecular Weight:236.046
Hs Code.:
DSSTox Substance ID:DTXSID80695079
Wikidata:Q82624087
Mol file:1093878-18-2.mol

Synonyms:5-BROMO-2-NITROTHIOPHENE-3-CARBALDEHYDE;1093878-18-2;5-Bromo-2-nitro-thiophene-3-carbaldehyde;SCHEMBL1428071;DTXSID80695079;FSWWDXRRJRWFTC-UHFFFAOYSA-N;MFCD13689137;BS-14303;CS-0157908;FT-0745749

Suppliers and Price of 5-Bromo-2-nitrothiophene-3-carbaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 5-Bromo-2-nitrothiophene-3-carbaldehyde

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:234.89388
Heavy Atom Count:11
Complexity:183

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(SC(=C1C=O)[N+](=O)[O-])Br

Technology Process of 5-Bromo-2-nitrothiophene-3-carbaldehyde

There total 1 articles about 5-Bromo-2-nitrothiophene-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1093878-17-1
5-bromo-3-(dichloromethyl)-2-nitrothiophene

: 1093878-18-2
5-bromo-2-nitrothiophene-3-carbaldehyde

Guidance literature:: 5-bromo-3-(dichloromethyl)-2-nitrothiophene; With zinc(II) chloride; In formic acid; Reflux;

With water; In formic acid; at 20 ℃;

Reference yield:

: 1093878-18-2
5-bromo-2-nitrothiophene-3-carbaldehyde

: 1093878-89-7
2-nitro-5-[4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,2,3-triazol-4-yl)phenyl]thiophene-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium acetate / ethanol / 20 °C

2: toluene-4-sulfonic acid; 1,2-bis-(diphenylphosphino)ethane / carbonyl bis(hydrido)tris(triphenylphosphine)ruthenium(II) / toluene / 24 h / 111 °C / Inert atmosphere

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 90 °C / Inert atmosphere

With hydroxylamine hydrochloride; sodium acetate; sodium carbonate; toluene-4-sulfonic acid; 1,2-bis-(diphenylphosphino)ethane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbonyl bis(hydrido)tris(triphenylphosphine)ruthenium(II); In tetrahydrofuran; ethanol; toluene;

Reference yield:

: 1093878-18-2
5-bromo-2-nitrothiophene-3-carbaldehyde

: 1093878-90-0
2-amino-5-[4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,2,3-triazol-4-yl)phenyl]thiophene-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride; sodium acetate / ethanol / 20 °C

2: toluene-4-sulfonic acid; 1,2-bis-(diphenylphosphino)ethane / carbonyl bis(hydrido)tris(triphenylphosphine)ruthenium(II) / toluene / 24 h / 111 °C / Inert atmosphere

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 90 °C / Inert atmosphere

4: hydrogen / 3percent Pt/C doped with 0.6percent V / methanol / 20 °C

With hydroxylamine hydrochloride; hydrogen; sodium acetate; sodium carbonate; toluene-4-sulfonic acid; 1,2-bis-(diphenylphosphino)ethane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbonyl bis(hydrido)tris(triphenylphosphine)ruthenium(II); In tetrahydrofuran; methanol; ethanol; toluene;