(4S,2S)-4-benzyl-2-(methoxy-methyl-carbamoyl)-oxazolidine-3-carboxylic acid-3-tert-butyl ester

Base Information

• Chemical Name: (4S,2S)-4-benzyl-2-(methoxy-methyl-carbamoyl)-oxazolidine-3-carboxylic acid-3-tert-butyl ester
• CAS No.: 362632-08-4
• Molecular Formula: C₁₈H₂₆N₂O₅
• Molecular Weight: 350.415
• Mol file: 362632-08-4.mol

Synonyms:(4S,2S)-4-benzyl-2-(methoxy-methyl-carbamoyl)-oxazolidine-3-carboxylic acid-3-tert-butyl ester

Chemical Property of (4S,2S)-4-benzyl-2-(methoxy-methyl-carbamoyl)-oxazolidine-3-carboxylic acid-3-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S,2S)-4-benzyl-2-(methoxy-methyl-carbamoyl)-oxazolidine-3-carboxylic acid-3-tert-butyl ester

There total 3 articles about (4S,2S)-4-benzyl-2-(methoxy-methyl-carbamoyl)-oxazolidine-3-carboxylic acid-3-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(4S,2S)-4-benzyl-oxazolidinone-2,3-dicarboxylic acid-3-tert-butyl ester (362632-07-3) + N,0-dimethylhydroxylamine (1117-97-1) → (4S,2S)-4-benzyl-2-(methoxy-methyl-carbamoyl)-oxazolidine-3-carboxylic acid-3-tert-butyl ester (362632-08-4)

Guidance literature:

With hydrogenchloride; isobutyl chloroformate;

DOI:10.1016/S0040-4020(01)00458-6

Reference yield:

L-Phenylalaninol (3182-95-4) → (4S,2S)-4-benzyl-2-(methoxy-methyl-carbamoyl)-oxazolidine-3-carboxylic acid-3-tert-butyl ester (362632-08-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 5.45 g / LiOH

2: 79 percent / isobutyl chloroformiate; HCl

With hydrogenchloride; lithium hydroxide; isobutyl chloroformate;

DOI:10.1016/S0040-4020(01)00458-6

Reference yield:

(2S,4S)-4-Benzyl-oxazolidine-2-carboxylic acid ethyl ester → (4S,2S)-4-benzyl-2-(methoxy-methyl-carbamoyl)-oxazolidine-3-carboxylic acid-3-tert-butyl ester (362632-08-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 5.45 g / LiOH

2: 79 percent / isobutyl chloroformiate; HCl

With hydrogenchloride; lithium hydroxide; isobutyl chloroformate;

DOI:10.1016/S0040-4020(01)00458-6

upstream raw materials:

(4S,2S)-4-benzyl-oxazolidinone-2,3-dicarboxylic acid-3-tert-butyl ester

N,0-dimethylhydroxylamine

L-Phenylalaninol

Downstream raw materials:

(2S,4S,9S)-4-benzyl-2-propionyl-oxazolidine-3-carboxylic acid-3-tert-butyl ester

(2S,4S,9R)-4-benzyl-2-propionyl-oxazolidine-3-carboxylic acid-3-tert-butyl ester

(4S,5S,6S)-4-allyl-3-(1-benzyl-2-hydroxy-ethyl)-5-ethyl-oxazolidin-2-one

(4R,5R,6S)-4-allyl-3-(1-benzyl-2-hydroxy-ethyl)-5-ethyl-oxazolidin-2-one