N,O-Dimethylhydroxylamine

Base Information

• Chemical Name: N,O-Dimethylhydroxylamine
• CAS No.: 1117-97-1
• Molecular Formula: C2H7NO
• Molecular Weight: 61.0837
• Hs Code.: 2922199090
• European Community (EC) Number: 214-255-2
• UNII: 783670HYEO
• DSSTox Substance ID: DTXSID5051577
• Nikkaji Number: J25.778H
• Wikipedia: N,O-Dimethylhydroxylamine
• Wikidata: Q6477050
• Mol file: 1117-97-1.mol

Synonyms:N,O-dimethylhydroxylamine

Chemical Property of N,O-Dimethylhydroxylamine

Chemical Property:

• Vapor Pressure: 1710mmHg at 25°C
• Melting Point: 97℃
• Refractive Index: 1.353
• Boiling Point: 2.908 °C at 760 mmHg
• PKA: 4.75±0.10(Predicted)
• Flash Point: -28.618 °C
• PSA: 21.26000
• Density: 0.796 g/cm³
• LogP: 0.15810
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 61.052763847
• Heavy Atom Count: 4
• Complexity: 10

Purity/Quality:

99.0% ^*data from raw suppliers

N,O-DIMETHYLHYDROXYLAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Hydroxylamines
• Canonical SMILES: CNOC

Technology Process of N,O-Dimethylhydroxylamine

There total 17 articles about N,O-Dimethylhydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → N,0-dimethylhydroxylamine (1117-97-1)

Guidance literature:

With sodium hydroxide; In N,N-dimethyl-formamide; distillation;

DOI:10.1021/ja00226a036

Reference yield:

dimethyl sulfate (77-78-1) → O-Methylhydroxylamin (67-62-9) + N,N-dimethylhydroxylamine (5725-96-2) + N,0-dimethylhydroxylamine (1117-97-1)

Guidance literature:

With hydroxylamine hemisulfate; sodium carbonate; sodium hydroxide; In water; at 2 - 5 ℃; for 2h;

Reference yield:

methylene chloride (74-87-3) → O-Methylhydroxylamin (67-62-9) + N,N-dimethylhydroxylamine (5725-96-2) + N,0-dimethylhydroxylamine (1117-97-1)

Guidance literature:

With hydroxylamine hydrochloride; sodium carbonate; sodium hydroxide; In water; at 2 - 5 ℃; for 2h; Concentration; Temperature;

upstream raw materials:

ethyl N-methoxy-N-methylcarbamate

N-methoxy-N-methyl-N'-phenylurea

N,O-Dimethylhydroxymethan

N,N-dimethylhydroxylamine

Downstream raw materials:

N-Methoxy-N-methyl-2,2-diethyl-3-carbamoyloxy-propanol-(1)

C₁₀H₁₀ClF₃N₂O₂

N-methyl-N-methoxy-3-bromopropionamide

N-methoxy-N-methylcarbamoyl chloride

Refernces

• 1、 Gilbreath,Harris,Harris. "Biomimetic syntheses of pretetramides. 1. Synthesis of pretetramide by tandem extension of a polyketide chain". . p. 6172 - 6179. Retrieved 1988.
• 2、 Shimada, Naoyuki,Ohse, Naoki,Takahashi, Naoya,Urata, Sari,Koshizuka, Masayoshi,Makino, Kazuishi. "Direct Synthesis of N -Protected Serine- And Threonine-Derived Weinreb Amides via Diboronic Acid Anhydride-Catalyzed Dehydrative Amidation: Application to the Concise Synthesis of -Garner's Aldehyde". supporting information. p. 1024 - 1028. Retrieved 2021/05/18.
• 3、 -. "One-pot method for preparing O-alkyl hydroxylamine hydrochloride and N,O-dialkyl hydroxylamine hydrochloride". Paragraph 0032-0033. . Retrieved 2020/10/20.