N,O-Dimethylhydroxylamine

Base Information

• Chemical Name: N,O-Dimethylhydroxylamine
• CAS No.: 1117-97-1
• Molecular Formula: C2H7NO
• Molecular Weight: 61.0837
• Hs Code.: 2922199090
• European Community (EC) Number: 214-255-2
• UNII: 783670HYEO
• DSSTox Substance ID: DTXSID5051577
• Nikkaji Number: J25.778H
• Wikipedia: N,O-Dimethylhydroxylamine
• Wikidata: Q6477050
• Mol file: 1117-97-1.mol

Synonyms:N,O-dimethylhydroxylamine

Chemical Property of N,O-Dimethylhydroxylamine

Chemical Property:

• Vapor Pressure: 1710mmHg at 25°C
• Melting Point: 97℃
• Refractive Index: 1.353
• Boiling Point: 2.908 °C at 760 mmHg
• PKA: 4.75±0.10(Predicted)
• Flash Point: -28.618 °C
• PSA: 21.26000
• Density: 0.796 g/cm³
• LogP: 0.15810
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 61.052763847
• Heavy Atom Count: 4
• Complexity: 10

Purity/Quality:

99.0% ^*data from raw suppliers

N,O-DIMETHYLHYDROXYLAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Hydroxylamines
• Canonical SMILES: CNOC

Technology Process of N,O-Dimethylhydroxylamine

There total 17 articles about N,O-Dimethylhydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → N,0-dimethylhydroxylamine (1117-97-1)

Guidance literature:

With sodium hydroxide; In N,N-dimethyl-formamide; distillation;

DOI:10.1021/ja00226a036

Reference yield:

dimethyl sulfate (77-78-1) → O-Methylhydroxylamin (67-62-9) + N,N-dimethylhydroxylamine (5725-96-2) + N,0-dimethylhydroxylamine (1117-97-1)

Guidance literature:

With hydroxylamine hemisulfate; sodium carbonate; sodium hydroxide; In water; at 2 - 5 ℃; for 2h;

Reference yield:

methylene chloride (74-87-3) → O-Methylhydroxylamin (67-62-9) + N,N-dimethylhydroxylamine (5725-96-2) + N,0-dimethylhydroxylamine (1117-97-1)

Guidance literature:

With hydroxylamine hydrochloride; sodium carbonate; sodium hydroxide; In water; at 2 - 5 ℃; for 2h; Concentration; Temperature;

upstream raw materials:

ethyl N-methoxy-N-methylcarbamate

N-methoxy-N-methyl-N'-phenylurea

N,O-Dimethylhydroxymethan

N,N-dimethylhydroxylamine

Downstream raw materials:

O,N,N-trimethyl hydroxylamine

N,N'-Dimethoxy-N,N'-dimethyl-benzyliden-diamin

C₁₁H₁₂ClF₃N₂O₃

N-methoxy-N-methyl-N'-[(4-trifluoromethyl)phenyl]-urea

Refernces

One-pot synthesis of aldehydes or ketones from carboxylic acids via in situ generation of Weinreb amides using the Deoxo-Fluor reagent

10.1016/j.tetlet.2006.06.121

The research focuses on the one-pot synthesis of aldehydes or ketones from carboxylic acids through the in situ generation of Weinreb amides using the Deoxo-Fluor reagent. The methodology involves the conversion of carboxylic acids to corresponding aldehydes and ketones with high yield, highlighting the efficiency of Weinreb amides in nucleophilic reactions with DIBAL-H and Grignard reagents. The experiments utilized various carboxylic acids, including aliphatic, aromatic, and unsaturated types, along with N,O-dimethylhydroxylamine and iPr2NEt as reactants. The Deoxo-Fluor reagent was employed to generate Weinreb amides in situ, which were then reacted with organometallic reagents to produce ketones or aldehydes. The analyses used to determine the yield and purity of the products included gas chromatography (GC), mass spectrometry (GC–MS), and nuclear magnetic resonance spectroscopy (1H and 13C NMR).