Phosphorous acid dibenzyl ester (1S,2R,3S,4S,5S,6S)-2,3,5-tris-benzyloxy-6-(bis-benzyloxy-phosphanyloxy)-4-(4-methoxy-benzyloxy)-cyclohexyl ester

Base Information

Chemical Name:Phosphorous acid dibenzyl ester (1S,2R,3S,4S,5S,6S)-2,3,5-tris-benzyloxy-6-(bis-benzyloxy-phosphanyloxy)-4-(4-methoxy-benzyloxy)-cyclohexyl ester
CAS No.:187841-49-2
Molecular Formula:C₆₃H₆₄O₁₁P₂
Molecular Weight:1059.14
Hs Code.:

Phosphorous acid dibenzyl ester (1S,2R,3S,4S,5S,6S)-2,3,5-tris-benzyloxy-6-(bis-benzyloxy-phosphanyloxy)-4-(4-methoxy-benzyloxy)-cyclohexyl ester

Synonyms:Phosphorous acid dibenzyl ester (1S,2R,3S,4S,5S,6S)-2,3,5-tris-benzyloxy-6-(bis-benzyloxy-phosphanyloxy)-4-(4-methoxy-benzyloxy)-cyclohexyl ester

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Chemical Property of Phosphorous acid dibenzyl ester (1S,2R,3S,4S,5S,6S)-2,3,5-tris-benzyloxy-6-(bis-benzyloxy-phosphanyloxy)-4-(4-methoxy-benzyloxy)-cyclohexyl ester

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Technology Process of Phosphorous acid dibenzyl ester (1S,2R,3S,4S,5S,6S)-2,3,5-tris-benzyloxy-6-(bis-benzyloxy-phosphanyloxy)-4-(4-methoxy-benzyloxy)-cyclohexyl ester

There total 15 articles about Phosphorous acid dibenzyl ester (1S,2R,3S,4S,5S,6S)-2,3,5-tris-benzyloxy-6-(bis-benzyloxy-phosphanyloxy)-4-(4-methoxy-benzyloxy)-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108549-23-1
Dibenzyl N,N-diisopropylphosphoramidite

: 141040-54-2
(+)-2,5,6-tri-O-benzyl-1-O-(p-methoxybenzyl)-myo-inositol

: 187841-49-2
Phosphorous acid dibenzyl ester (1S,2R,3S,4S,5S,6S)-2,3,5-tris-benzyloxy-6-(bis-benzyloxy-phosphanyloxy)-4-(4-methoxy-benzyloxy)-cyclohexyl ester

Guidance literature:: With 1H-tetrazole; In dichloromethane; acetonitrile; at 20 ℃; for 1h;
DOI:10.1016/S0008-6215(96)00211-X

Reference yield:

: 140887-04-3
(+/-)-2,5,6-Tri-O-benzyl-3,4-O-isopropylidene-1-O-p-methoxybenzyl-myo-inositol

: 187841-49-2
Phosphorous acid dibenzyl ester (1S,2R,3S,4S,5S,6S)-2,3,5-tris-benzyloxy-6-(bis-benzyloxy-phosphanyloxy)-4-(4-methoxy-benzyloxy)-cyclohexyl ester

Guidance literature:: Multi-step reaction with 2 steps

2: 1H-tetrazole / acetonitrile; CH₂Cl₂ / 1 h / 20 °C

With 1H-tetrazole; In dichloromethane; acetonitrile;
DOI:10.1016/S0008-6215(96)00211-X

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 187841-49-2
Phosphorous acid dibenzyl ester (1S,2R,3S,4S,5S,6S)-2,3,5-tris-benzyloxy-6-(bis-benzyloxy-phosphanyloxy)-4-(4-methoxy-benzyloxy)-cyclohexyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) Bu₂SnO, Bu₄NBr / 1.) MeCN, reflux, 4 h, 2.) reflux, 12 h

2: 98 percent / NaH / dimethylformamide

3: KOBu-t / dimethylsulfoxide / 4 h / 50 °C

4: HCl/acetone / methanol / 0.33 h / Heating

5: p-TsOH / acetone / 2 h / 20 °C

6: NaH / dimethylformamide

8: 1H-tetrazole / acetonitrile; CH₂Cl₂ / 1 h / 20 °C

With 1H-tetrazole; hydrogenchloride; potassium tert-butylate; tetrabutylammomium bromide; sodium hydride; di(n-butyl)tin oxide; toluene-4-sulfonic acid; acetone; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1016/S0008-6215(96)00211-X