3-bromo-4-propylaniline

Base Information

• Chemical Name: 3-bromo-4-propylaniline
• CAS No.: 3355-22-4
• Molecular Formula: C₉H₁₂BrN
• Molecular Weight: 214.105
• Mol file: 3355-22-4.mol

Synonyms:3-bromo-4-propylaniline

Chemical Property of 3-bromo-4-propylaniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-bromo-4-propylaniline

There total 1 articles about 3-bromo-4-propylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

2-bromo-4-nitro-1-propylbenzene (3355-09-7) → 3-bromo-4-propylaniline (3355-22-4)

Guidance literature:

With hydrogenchloride; tin(II) chloride dihdyrate; at 70 ℃; for 3h;

Reference yield: 84.0%

3-bromo-4-propylaniline (3355-22-4) + diethyl 2-ethoxymethylenemalonate (87-13-8) → diethyl 2-((3-bromo-4-propylphenylamino)methylene)malonate (1445789-50-3)

Guidance literature:

In ethanol; at 70 ℃; for 1h;

Reference yield:

3-bromo-4-propylaniline (3355-22-4) → 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-propylquinolin-4-yl)amino)-5-cyclopentylbenzoic acid (1445786-76-4)

Guidance literature:

Multi-step reaction with 8 steps

1: ethanol / 1 h / 70 °C

2: diphenylether / Reflux

3: sodium hydroxide; water / methanol / 2 h / 50 °C

4: trichlorophosphate / 3 h / 103 °C

5: ammonium hydroxide / tetrahydrofuran / 0 °C

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 2.5 h / 80 °C / Inert atmosphere

7: ethanol / 1 h / Reflux

8: water; lithium hydroxide / tetrahydrofuran / 20 - 25 °C

With ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate; sodium hydroxide; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; diphenylether; ethanol; water;

upstream raw materials:

2-bromo-4-nitro-1-propylbenzene

Downstream raw materials:

3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-propylquinolin-4-yl)amino)-5-cyclopentylbenzoic acid

methyl 3-(3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-propylquinolin-4-ylamino)-5-cyclopentylbenzoate

diethyl 2-((3-bromo-4-propylphenylamino)methylene)malonate

Refernces