3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-propylquinolin-4-yl)amino)-5-cyclopentylbenzoic acid

Base Information

Chemical Name:3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-propylquinolin-4-yl)amino)-5-cyclopentylbenzoic acid
CAS No.:1445786-76-4
Molecular Formula:C₃₁H₃₃N₅O₅
Molecular Weight:555.634
Hs Code.:

Synonyms:3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-propylquinolin-4-yl)amino)-5-cyclopentylbenzoic acid

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Chemical Property of 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-propylquinolin-4-yl)amino)-5-cyclopentylbenzoic acid

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Technology Process of 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-propylquinolin-4-yl)amino)-5-cyclopentylbenzoic acid

There total 11 articles about 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-propylquinolin-4-yl)amino)-5-cyclopentylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1445789-60-5
methyl 3-(3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-propylquinolin-4-ylamino)-5-cyclopentylbenzoate

: 1445786-76-4
3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-propylquinolin-4-yl)amino)-5-cyclopentylbenzoic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 - 25 ℃;

Reference yield:

: 6307-87-5
methyl 3-bromo-5-nitrobenzoate

: 1445786-76-4
3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-propylquinolin-4-yl)amino)-5-cyclopentylbenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

2: hydrogen; acetic acid; palladium 10% on activated carbon / methanol / 12 h / 50 °C

3: ethanol / 1 h / Reflux

4: water; lithium hydroxide / tetrahydrofuran / 20 - 25 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; acetic acid; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1445789-56-9
7-bromo-4-chloro-6-propylquinoline-3-carboxamide

: 1445786-76-4
3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-propylquinolin-4-yl)amino)-5-cyclopentylbenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 2.5 h / 80 °C / Inert atmosphere

2: ethanol / 1 h / Reflux

3: water; lithium hydroxide / tetrahydrofuran / 20 - 25 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; water;