Technology Process of (2E,5S,6S,7R,8E)-((2S,3S)-1-(benzyloxy)-3-methyl-1-oxopentan-2-yl) 7-(tert-butyldimethylsilyloxy)-5-(methoxymethoxy)-2,6,8-trimethyldeca-2,8-dienoate
There total 10 articles about (2E,5S,6S,7R,8E)-((2S,3S)-1-(benzyloxy)-3-methyl-1-oxopentan-2-yl) 7-(tert-butyldimethylsilyloxy)-5-(methoxymethoxy)-2,6,8-trimethyldeca-2,8-dienoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2S,3S)-benzyl 2-(2-(diethoxyphosphoryl)propanoyloxy)-3-methylpentanoate;
With
N-ethyl-N,N-diisopropylamine; lithium chloride;
In
acetonitrile;
at 20 ℃;
for 0.333333h;
C18H36O4Si;
In
acetonitrile;
at 20 ℃;
for 20h;
DOI:10.1016/j.tetlet.2014.04.079
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 2,6-dimethylpyridine / dichloromethane / 0.5 h / 0 - 20 °C
2.1: lithium borohydride / tetrahydrofuran; methanol / 1 h / 0 - 20 °C
3.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 1 h / 0 °C
4.1: di-n-butylboryl trifluoromethanesulfonate / dichloromethane / 0.17 h / 0 °C
4.2: 0.75 h / -78 - 0 °C
4.3: 2 h / -78 °C
5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C
6.1: lithium borohydride / tetrahydrofuran; methanol / 1 h / 0 °C
7.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 1 h / 0 °C
8.1: N-ethyl-N,N-diisopropylamine; lithium chloride / acetonitrile / 0.33 h / 20 °C
8.2: 20 h / 20 °C
With
2,6-dimethylpyridine; lithium borohydride; di-n-butylboryl trifluoromethanesulfonate; sulfur trioxide pyridine complex; triethylamine; N-ethyl-N,N-diisopropylamine; lithium chloride;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/j.tetlet.2014.04.079
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 1 h / 0 °C
2.1: di-n-butylboryl trifluoromethanesulfonate / dichloromethane / 0.17 h / 0 °C
2.2: 0.75 h / -78 - 0 °C
2.3: 2 h / -78 °C
3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C
4.1: lithium borohydride / tetrahydrofuran; methanol / 1 h / 0 °C
5.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 1 h / 0 °C
6.1: N-ethyl-N,N-diisopropylamine; lithium chloride / acetonitrile / 0.33 h / 20 °C
6.2: 20 h / 20 °C
With
lithium borohydride; di-n-butylboryl trifluoromethanesulfonate; sulfur trioxide pyridine complex; triethylamine; N-ethyl-N,N-diisopropylamine; lithium chloride;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/j.tetlet.2014.04.079
