2-(2-(2-(diethylamino)-2-oxoacetamido)propan-2-yl)-4-(4-fluorobenzylcarbamoyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-5-yl benzoate

Base Information

• Chemical Name: 2-(2-(2-(diethylamino)-2-oxoacetamido)propan-2-yl)-4-(4-fluorobenzylcarbamoyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-5-yl benzoate
• CAS No.: 1370588-62-7
• Molecular Formula: C₂₉H₃₂FN₅O₆
• Molecular Weight: 565.601
• Mol file: 1370588-62-7.mol

Synonyms:2-(2-(2-(diethylamino)-2-oxoacetamido)propan-2-yl)-4-(4-fluorobenzylcarbamoyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-5-yl benzoate

Chemical Property of 2-(2-(2-(diethylamino)-2-oxoacetamido)propan-2-yl)-4-(4-fluorobenzylcarbamoyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-5-yl benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-(2-(diethylamino)-2-oxoacetamido)propan-2-yl)-4-(4-fluorobenzylcarbamoyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-5-yl benzoate

There total 7 articles about 2-(2-(2-(diethylamino)-2-oxoacetamido)propan-2-yl)-4-(4-fluorobenzylcarbamoyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-5-yl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N1,N1-diethyl-N2-(2-(4-(4-fluorobenzylcarbamoyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)propan-2-yl)oxalamide (1370588-59-2) + benzoyl chloride (98-88-4) → 2-(2-(2-(diethylamino)-2-oxoacetamido)propan-2-yl)-4-(4-fluorobenzylcarbamoyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-5-yl benzoate (1370588-62-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/j.ejmech.2012.02.015

Reference yield:

methyl 2-(2(((benzyloxy)carbonyl)amino)propan-2-yl)-5,6-dihydroxy-1,6-dihydropyrimidine-4-carboxylate → 2-(2-(2-(diethylamino)-2-oxoacetamido)propan-2-yl)-4-(4-fluorobenzylcarbamoyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-5-yl benzoate (1370588-62-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: pyridine / 10 h / 20 °C

2.1: lithium hydride / 1,4-dioxane / 1 h / 40 °C

2.2: 3 h / 60 °C

3.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; water / 3 h / 760.05 Torr

4.1: triethylamine / dichloromethane; N,N-dimethyl-formamide / 2.25 h

5.1: methanol / 20 h / Reflux; Inert atmosphere

5.3: 0 °C / pH 2

6.1: triethylamine / dichloromethane / 3 h / 20 °C

With pyridine; hydrogenchloride; palladium 10% on activated carbon; hydrogen; lithium hydride; triethylamine; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2012.02.015

Reference yield:

methyl 5-(benzoyloxy)-2-(1-{[(benzyloxy)carbonyl]amino}-1-methylethyl)-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylate (518048-01-6) → 2-(2-(2-(diethylamino)-2-oxoacetamido)propan-2-yl)-4-(4-fluorobenzylcarbamoyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-5-yl benzoate (1370588-62-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; water / 3 h / 760.05 Torr

2.1: triethylamine / dichloromethane; N,N-dimethyl-formamide / 2.25 h

3.1: methanol / 20 h / Reflux; Inert atmosphere

3.3: 0 °C / pH 2

4.1: triethylamine / dichloromethane / 3 h / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2012.02.015

upstream raw materials:

methyl 5-(benzoyloxy)-2-(1-{[(benzyloxy)carbonyl]amino}-1-methylethyl)-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylate

2-[5-(benzoyloxy)-4-(methoxycarbonyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl]propan-2-amine hydrochloride

methyl 5-(benzoyloxy)-2-(2-(2-(diethylamino)-2-oxoacetamido)propan-2-yl)-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylate

N₁,N₁-diethyl-N₂-(2-(4-(4-fluorobenzylcarbamoyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)propan-2-yl)oxalamide