7-chloro-α-(2-chloroacetylamino)-5-(2-chlorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-ylidene acetic acid methyl ester

Base Information

Chemical Name:7-chloro-α-(2-chloroacetylamino)-5-(2-chlorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-ylidene acetic acid methyl ester
CAS No.:87216-18-0
Molecular Formula:C₂₀H₁₆Cl₃N₃O₃
Molecular Weight:452.724
Hs Code.:

Synonyms:7-chloro-α-(2-chloroacetylamino)-5-(2-chlorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-ylidene acetic acid methyl ester

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Chemical Property of 7-chloro-α-(2-chloroacetylamino)-5-(2-chlorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-ylidene acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 7-chloro-α-(2-chloroacetylamino)-5-(2-chlorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-ylidene acetic acid methyl ester

There total 1 articles about 7-chloro-α-(2-chloroacetylamino)-5-(2-chlorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-ylidene acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: α-amino-7-chloro-5-(2-chlorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-ylidene acetic acid methyl ester ethanolate

: 79-04-9
chloroacetyl chloride

: 87216-18-0
7-chloro-α-(2-chloroacetylamino)-5-(2-chlorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-ylidene acetic acid methyl ester

Guidance literature:: In dichloromethane; for 0.0833333h; Heating;
DOI:10.1002/jhet.5570200357

Reference yield: 74.0%

: 87216-18-0
7-chloro-α-(2-chloroacetylamino)-5-(2-chlorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-ylidene acetic acid methyl ester

: 87216-19-1
9-chloro-7-(2-chlorophenyl)-2-oxo-1,2,3,5-tetrahydropyrazino<1,2-a><1,4>-benzodiazepine-4-carboxylic acid methyl ester

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; for 0.0833333h; Heating;
DOI:10.1002/jhet.5570200357

Reference yield:

: 87216-18-0
7-chloro-α-(2-chloroacetylamino)-5-(2-chlorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-ylidene acetic acid methyl ester

: 87216-22-6
9-chloro-7-(2-chlorophenyl)-2-oxo-1,2,3,5-tetrahydropyrazino<1,2-a><1,4>benzodiazepine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / triethylamine / dimethylformamide / 0.08 h / Heating

2: 79 percent / KOH; acetic acid / methanol; H₂O / 2.5 h / Heating

With potassium hydroxide; acetic acid; triethylamine; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570200357