7-(4-Formyl-phenyl)-1,3-dioxo-1H,3H-benzo[de]isochromene-6-carboxylic acid 2,2,2-trichloro-ethyl ester

Base Information

Chemical Name:7-(4-Formyl-phenyl)-1,3-dioxo-1H,3H-benzo[de]isochromene-6-carboxylic acid 2,2,2-trichloro-ethyl ester
CAS No.:199169-35-2
Molecular Formula:C₂₂H₁₁Cl₃O₆
Molecular Weight:477.685
Hs Code.:

Synonyms:7-(4-Formyl-phenyl)-1,3-dioxo-1H,3H-benzo[de]isochromene-6-carboxylic acid 2,2,2-trichloro-ethyl ester

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Chemical Property of 7-(4-Formyl-phenyl)-1,3-dioxo-1H,3H-benzo[de]isochromene-6-carboxylic acid 2,2,2-trichloro-ethyl ester

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Technology Process of 7-(4-Formyl-phenyl)-1,3-dioxo-1H,3H-benzo[de]isochromene-6-carboxylic acid 2,2,2-trichloro-ethyl ester

There total 4 articles about 7-(4-Formyl-phenyl)-1,3-dioxo-1H,3H-benzo[de]isochromene-6-carboxylic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 87199-17-5
4-formylphenylboronic acid,

: 199169-34-1
7-Bromo-1,3-dioxo-1H,3H-benzo[de]isochromene-6-carboxylic acid 2,2,2-trichloro-ethyl ester

: 199169-35-2
7-(4-Formyl-phenyl)-1,3-dioxo-1H,3H-benzo[de]isochromene-6-carboxylic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: With palladium diacetate; potassium carbonate; In tetrahydrofuran; for 20h; Heating;
DOI:10.1021/jo9714167

Reference yield:

: 91805-60-6
5-Bromoacenaphthene-6-carboxylic acid

: 199169-35-2
7-(4-Formyl-phenyl)-1,3-dioxo-1H,3H-benzo[de]isochromene-6-carboxylic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: (COCl)2, DMF / CH₂Cl₂ / 0.33 h / Ambient temperature

2: 2.21 g / DMAP / CH₂Cl₂ / 8 h / Ambient temperature

3: 100 percent / K₂Cr₂O₇ / aq. acetic acid / 24 h / Heating

4: 64 percent / Pd(OAc)2, K₂CO₃ / tetrahydrofuran / 20 h / Heating

With dmap; potassium dichromate; palladium diacetate; oxalyl dichloride; potassium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; acetic acid;
DOI:10.1021/jo9714167

Reference yield:

: 6-Bromo-acenaphthene-5-carbonyl chloride

: 199169-35-2
7-(4-Formyl-phenyl)-1,3-dioxo-1H,3H-benzo[de]isochromene-6-carboxylic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 2.21 g / DMAP / CH₂Cl₂ / 8 h / Ambient temperature

2: 100 percent / K₂Cr₂O₇ / aq. acetic acid / 24 h / Heating

3: 64 percent / Pd(OAc)2, K₂CO₃ / tetrahydrofuran / 20 h / Heating

With dmap; potassium dichromate; palladium diacetate; potassium carbonate; In tetrahydrofuran; dichloromethane; acetic acid;
DOI:10.1021/jo9714167