N-benzy-N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-L-alanine tert-butyl ester

Base Information

Chemical Name:N-benzy-N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-L-alanine tert-butyl ester
CAS No.:256478-37-2
Molecular Formula:C₂₄H₂₈ClN₅O₄S
Molecular Weight:518.036
Hs Code.:

Synonyms:N-benzy-N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-L-alanine tert-butyl ester

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Chemical Property of N-benzy-N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-L-alanine tert-butyl ester

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Technology Process of N-benzy-N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-L-alanine tert-butyl ester

There total 9 articles about N-benzy-N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-L-alanine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 256477-48-2
N-benzyl-N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-L-alanine tert-butyl ester

: 50-01-1
guanidine hydrochloride

: 256478-37-2
N-benzy-N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-L-alanine tert-butyl ester

Guidance literature:: guanidine hydrochloride; With sodium hydride; In 1,2-dimethoxyethane; at 60 ℃; for 0.75h;

N-benzyl-N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-L-alanine tert-butyl ester; In 1,2-dimethoxyethane; at 95 ℃; for 4h; Further stages.;
DOI:10.1021/jm061066t

Reference yield:

: 223671-80-5
1,4-dichloro-7-isoquinolinesulphonyl chloride

: 256478-37-2
N-benzy-N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-L-alanine tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 470 mg / NEt₃ / CH₂Cl₂ / 24 h / 20 °C

2.1: NaH / 1,2-dimethoxy-ethane / 0.75 h / 60 °C

2.2: 120 mg / 1,2-dimethoxy-ethane / 4 h / 95 °C

With sodium hydride; triethylamine; In 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/jm061066t

Reference yield:

: 223671-81-6
4-chloro-1-oxo-1,2-dihydro-7-isoquinolinesulfonyl chloride

: 256478-37-2
N-benzy-N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-L-alanine tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 20 g / POCl₃ / acetonitrile / 15 h / Heating

2.1: 470 mg / NEt₃ / CH₂Cl₂ / 24 h / 20 °C

3.1: NaH / 1,2-dimethoxy-ethane / 0.75 h / 60 °C

3.2: 120 mg / 1,2-dimethoxy-ethane / 4 h / 95 °C

With sodium hydride; triethylamine; trichlorophosphate; In 1,2-dimethoxyethane; dichloromethane; acetonitrile;
DOI:10.1021/jm061066t