1-(tert-butyldimethylsilylioxy)methyl-5-chloro-3,4-dihydro-4-phenyl-2(1H)-pyrimidinone

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Chemical Name:1-(tert-butyldimethylsilylioxy)methyl-5-chloro-3,4-dihydro-4-phenyl-2(1H)-pyrimidinone
CAS No.:119451-83-1
Molecular Formula:C₁₇H₂₅ClN₂O₂Si
Molecular Weight:352.936
Hs Code.:

Synonyms:1-(tert-butyldimethylsilylioxy)methyl-5-chloro-3,4-dihydro-4-phenyl-2(1H)-pyrimidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(tert-butyldimethylsilylioxy)methyl-5-chloro-3,4-dihydro-4-phenyl-2(1H)-pyrimidinone

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Technology Process of 1-(tert-butyldimethylsilylioxy)methyl-5-chloro-3,4-dihydro-4-phenyl-2(1H)-pyrimidinone

There total 4 articles about 1-(tert-butyldimethylsilylioxy)methyl-5-chloro-3,4-dihydro-4-phenyl-2(1H)-pyrimidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: phenylmagnesium bromide

: 119451-81-9
1-(tert-butyldimethylsilyloxy)methyl-5-chloro-2(1H)-pyrimidinone

: 1-(tert-butyldimethylsilyloxy)methyl-5-chloro-3,6-dihydro-6-phenyl-2(1H)-pyrimidinone

: 119451-83-1
1-(tert-butyldimethylsilylioxy)methyl-5-chloro-3,4-dihydro-4-phenyl-2(1H)-pyrimidinone

Guidance literature:: In tetrahydrofuran; for 20h; ambient temperature;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 119451-83-1
1-(tert-butyldimethylsilylioxy)methyl-5-chloro-3,4-dihydro-4-phenyl-2(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / 4-(N,N-dimethylamino)pyridine, Et₃N / CH₂Cl₂ / 4 h

2: 97 percent / SO₂Cl₂ / CH₂Cl₂ / 0 deg C, 30 min -> ambient temperature, 10 min

3: 53 percent / Et₃N / CH₂Cl₂ / -78 deg C -> ambient temperature, during 23 h

4: 33 percent / tetrahydrofuran / 20 h / ambient temperature

With dmap; sulfuryl dichloride; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 119451-79-5
(1,1-dimethylethyl)[(ethylthio)methoxy]dimethylsilane

: 119451-83-1
1-(tert-butyldimethylsilylioxy)methyl-5-chloro-3,4-dihydro-4-phenyl-2(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / SO₂Cl₂ / CH₂Cl₂ / 0 deg C, 30 min -> ambient temperature, 10 min

2: 53 percent / Et₃N / CH₂Cl₂ / -78 deg C -> ambient temperature, during 23 h

3: 33 percent / tetrahydrofuran / 20 h / ambient temperature

With sulfuryl dichloride; triethylamine; In tetrahydrofuran; dichloromethane;