(2Z,3E)-methyl 2-benzylidene-4-(4-(trifluoromethyl)phenyl)but-3-enoate

Base Information

• Chemical Name: (2Z,3E)-methyl 2-benzylidene-4-(4-(trifluoromethyl)phenyl)but-3-enoate
• CAS No.: 959703-01-6
• Molecular Formula: C₁₉H₁₅F₃O₂
• Molecular Weight: 332.322
• Mol file: 959703-01-6.mol

Synonyms:(2Z,3E)-methyl 2-benzylidene-4-(4-(trifluoromethyl)phenyl)but-3-enoate

Chemical Property of (2Z,3E)-methyl 2-benzylidene-4-(4-(trifluoromethyl)phenyl)but-3-enoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2Z,3E)-methyl 2-benzylidene-4-(4-(trifluoromethyl)phenyl)but-3-enoate

There total 2 articles about (2Z,3E)-methyl 2-benzylidene-4-(4-(trifluoromethyl)phenyl)but-3-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Trifluoromethylbenzaldehyde (455-19-6) + methyl 3-methoxy-3-phenyl-2-methylene-propanoate (189089-27-8) → methyl (E)-2-((E)-benzylidene)-4-(4-(trifluoromethyl)phenyl)but-3-enoate + (2Z,3E)-methyl 2-benzylidene-4-(4-(trifluoromethyl)phenyl)but-3-enoate (959703-01-6)

Guidance literature:

With titanium(IV) isopropylate; tributylphosphine; In tetrahydrofuran; at 20 ℃; for 15h;

DOI:10.1039/b709157e

Reference yield:

4-Trifluoromethylbenzaldehyde (455-19-6) + methyl 3-hydroxy-2-methylidene-3-phenylpropionate (18020-59-2) → methyl (E)-2-((E)-benzylidene)-4-(4-(trifluoromethyl)phenyl)but-3-enoate + (2Z,3E)-methyl 2-benzylidene-4-(4-(trifluoromethyl)phenyl)but-3-enoate (959703-01-6) + methyl 2-(benzylidene)-4-(4-(trifluoromethyl)phenyl)but-3-enoate

Guidance literature:

With calcium(II) bis(trifluoromethanesulfonyl)imide; water; potassium trifluoroacetate; triphenylphosphine; In isopropyl alcohol; at 100 ℃; for 24h; Overall yield = 89 %; Overall yield = 118.58 mg; Inert atmosphere;

DOI:10.1021/acs.orglett.9b01349

upstream raw materials:

4-Trifluoromethylbenzaldehyde

methyl 3-methoxy-3-phenyl-2-methylene-propanoate

methyl 3-hydroxy-2-methylidene-3-phenylpropionate