Technology Process of 4-benzyl 3-tert-butyl (2S,4S)-2-tert-butyl-4-((R)-1-(4-methoxybenzyloxy)allyl)oxazolidine-3,4-dicarboxylate
There total 9 articles about 4-benzyl 3-tert-butyl (2S,4S)-2-tert-butyl-4-((R)-1-(4-methoxybenzyloxy)allyl)oxazolidine-3,4-dicarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 0.5 h / 20 °C / Inert atmosphere
2: chloro-trimethyl-silane; lithium hexamethyldisilazane / tetrahydrofuran / -78 - 23 °C / Inert atmosphere
3: potassium carbonate / acetone / 4 h / 23 °C / Inert atmosphere
With
dmap; chloro-trimethyl-silane; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; acetone;
2: Ireland-Claisen rearrangement;
DOI:10.1021/ol203300k
- Guidance literature:
-
Multi-step reaction with 2 steps
1: chloro-trimethyl-silane; lithium hexamethyldisilazane / tetrahydrofuran / -78 - 23 °C / Inert atmosphere
2: potassium carbonate / acetone / 4 h / 23 °C / Inert atmosphere
With
chloro-trimethyl-silane; potassium carbonate; lithium hexamethyldisilazane;
In
tetrahydrofuran; acetone;
1: Ireland-Claisen rearrangement;
DOI:10.1021/ol203300k
- Guidance literature:
-
Multi-step reaction with 6 steps
1: triethylamine / pentane / 72 h / 55 °C / Dean Stark conditions
2: sodium hydrogencarbonate / methanol / 18 h / 50 °C / Inert atmosphere
3: water; potassium hydroxide / methanol / 0 - 20 °C / Inert atmosphere
4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 0.5 h / 20 °C / Inert atmosphere
5: chloro-trimethyl-silane; lithium hexamethyldisilazane / tetrahydrofuran / -78 - 23 °C / Inert atmosphere
6: potassium carbonate / acetone / 4 h / 23 °C / Inert atmosphere
With
dmap; chloro-trimethyl-silane; water; sodium hydrogencarbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; dichloromethane; acetone; pentane;
5: Ireland-Claisen rearrangement;
DOI:10.1021/ol203300k
