tert-butyl 3-(4-amino-5-(4-(4-(trifluoromethyl)pyridin-2-ylcarbamoyl)phenyl)pyrrolo[1,2-f][1,2,4]triazin-7-yl)piperidine-1-carboxylate

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Chemical Name:tert-butyl 3-(4-amino-5-(4-(4-(trifluoromethyl)pyridin-2-ylcarbamoyl)phenyl)pyrrolo[1,2-f][1,2,4]triazin-7-yl)piperidine-1-carboxylate
CAS No.:1419222-92-6
Molecular Formula:C₂₉H₃₀F₃N₇O₃
Molecular Weight:581.598
Hs Code.:

Synonyms:tert-butyl 3-(4-amino-5-(4-(4-(trifluoromethyl)pyridin-2-ylcarbamoyl)phenyl)pyrrolo[1,2-f][1,2,4]triazin-7-yl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 3-(4-amino-5-(4-(4-(trifluoromethyl)pyridin-2-ylcarbamoyl)phenyl)pyrrolo[1,2-f][1,2,4]triazin-7-yl)piperidine-1-carboxylate

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Technology Process of tert-butyl 3-(4-amino-5-(4-(4-(trifluoromethyl)pyridin-2-ylcarbamoyl)phenyl)pyrrolo[1,2-f][1,2,4]triazin-7-yl)piperidine-1-carboxylate

There total 5 articles about tert-butyl 3-(4-amino-5-(4-(4-(trifluoromethyl)pyridin-2-ylcarbamoyl)phenyl)pyrrolo[1,2-f][1,2,4]triazin-7-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 937047-57-9
rac-tert-butyl 3-(4-amino-5-bromopyrrolo[2,1-f][1,2,4]triazin-7-yl)piperidine-1-carboxylate

: 1418307-30-8
4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-N-(4-trifluoromethyl-pyridin-2-yl)-benzamide

: 1419222-92-6
tert-butyl 3-(4-amino-5-(4-(4-(trifluoromethyl)pyridin-2-ylcarbamoyl)phenyl)pyrrolo[1,2-f][1,2,4]triazin-7-yl)piperidine-1-carboxylate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; for 6h; Inert atmosphere; Reflux;

Reference yield:

: 937047-55-7
tert-butyl 3-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5,6-dihydropyridine-1(2H)-carboxylate

: 1419222-92-6
tert-butyl 3-(4-amino-5-(4-(4-(trifluoromethyl)pyridin-2-ylcarbamoyl)phenyl)pyrrolo[1,2-f][1,2,4]triazin-7-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; hydrogen; palladium 10% on activated carbon / ethanol / 35 °C / 37503.8 Torr

2: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / N,N-dimethyl-formamide / 1.5 h / -50 - 0 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane / 6 h / Inert atmosphere; Reflux

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 937047-56-8
rac-tert-butyl 3-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)piperidine-1-carboxylate

: 1419222-92-6
tert-butyl 3-(4-amino-5-(4-(4-(trifluoromethyl)pyridin-2-ylcarbamoyl)phenyl)pyrrolo[1,2-f][1,2,4]triazin-7-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / N,N-dimethyl-formamide / 1.5 h / -50 - 0 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane / 6 h / Inert atmosphere; Reflux

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; potassium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide;