5-(3,4-difluorophenyl)-3-cyclobutylimino-2-(2-methoxy-3-pyridyl)amino-3,5-dihydrophenazine

Base Information

Chemical Name:5-(3,4-difluorophenyl)-3-cyclobutylimino-2-(2-methoxy-3-pyridyl)amino-3,5-dihydrophenazine
CAS No.:1353732-37-2
Molecular Formula:C₂₈H₂₃F₂N₅O
Molecular Weight:483.52
Hs Code.:

Synonyms:5-(3,4-difluorophenyl)-3-cyclobutylimino-2-(2-methoxy-3-pyridyl)amino-3,5-dihydrophenazine

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Chemical Property of 5-(3,4-difluorophenyl)-3-cyclobutylimino-2-(2-methoxy-3-pyridyl)amino-3,5-dihydrophenazine

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Technology Process of 5-(3,4-difluorophenyl)-3-cyclobutylimino-2-(2-methoxy-3-pyridyl)amino-3,5-dihydrophenazine

There total 9 articles about 5-(3,4-difluorophenyl)-3-cyclobutylimino-2-(2-methoxy-3-pyridyl)amino-3,5-dihydrophenazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2516-34-9
cyclobutylamine

: 5-(3,4-difluorophenyl)-3-imino-2-(2-methoxy-3-pyridyl)amino-3,5-dihydrophenazine

: 1353732-37-2
5-(3,4-difluorophenyl)-3-cyclobutylimino-2-(2-methoxy-3-pyridyl)amino-3,5-dihydrophenazine

Guidance literature:: With acetic acid; In 1,4-dioxane; at 110 ℃; Sealed tube;
DOI:10.3390/molecules19044380

Reference yield:

: 1-[2-(3,4-difluoroanilino)anilino]-3-fluoro-4,6-dinitrobenzene

: 1353732-37-2
5-(3,4-difluorophenyl)-3-cyclobutylimino-2-(2-methoxy-3-pyridyl)amino-3,5-dihydrophenazine

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 31 h / Reflux

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 15 h / 20 °C / 2068.65 Torr

3: methanol / 18 h / 20 °C

4: acetic acid / 1,4-dioxane / 110 °C / Sealed tube

With palladium 10% on activated carbon; hydrogen; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.3390/molecules19044380

Reference yield:

: 1-[2-(3,4-difluoroanilino)anilino]-3-(2-methoxy-3-pyridyl)amino-4,6-dinitrobenzene

: 1353732-37-2
5-(3,4-difluorophenyl)-3-cyclobutylimino-2-(2-methoxy-3-pyridyl)amino-3,5-dihydrophenazine

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 15 h / 20 °C / 2068.65 Torr

2: methanol / 18 h / 20 °C

3: acetic acid / 1,4-dioxane / 110 °C / Sealed tube

With palladium 10% on activated carbon; hydrogen; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.3390/molecules19044380