(R)-3-((R)-2-(3,4,5-trimethoxyphenyl)propanoyl)-4-isopropyloxazolidin-2-one

Base Information

• Chemical Name: (R)-3-((R)-2-(3,4,5-trimethoxyphenyl)propanoyl)-4-isopropyloxazolidin-2-one
• CAS No.: 931103-13-8
• Molecular Formula: C₁₈H₂₅NO₆
• Molecular Weight: 351.4
• Mol file: 931103-13-8.mol

Synonyms:(R)-3-((R)-2-(3,4,5-trimethoxyphenyl)propanoyl)-4-isopropyloxazolidin-2-one

Chemical Property of (R)-3-((R)-2-(3,4,5-trimethoxyphenyl)propanoyl)-4-isopropyloxazolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-((R)-2-(3,4,5-trimethoxyphenyl)propanoyl)-4-isopropyloxazolidin-2-one

There total 2 articles about (R)-3-((R)-2-(3,4,5-trimethoxyphenyl)propanoyl)-4-isopropyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(R)-4-isopropyl-3-(2-(3,4,5-trimethoxyphenyl)acetyl)oxazolidin-2-one + methyl iodide (74-88-4) → (R)-3-((R)-2-(3,4,5-trimethoxyphenyl)propanoyl)-4-isopropyloxazolidin-2-one (931103-13-8)

Guidance literature:

(R)-4-isopropyl-3-(2-(3,4,5-trimethoxyphenyl)acetyl)oxazolidin-2-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

methyl iodide; In tetrahydrofuran; at -78 - 0 ℃; for 2h;

Reference yield:

(R)-4-isopropyl-3-(2-(3,4,5-trimethoxyphenyl)acetyl)oxazolidin-2-one + methyl iodide (74-88-4) → (R)-3-((R)-2-(3,4,5-trimethoxyphenyl)propanoyl)-4-isopropyloxazolidin-2-one (931103-13-8) + (R)-3-((S)-2-(3,4,5-trimethoxyphenyl)propanoyl)-4-isopropyloxazolidin-2-one

Guidance literature:

(R)-4-isopropyl-3-(2-(3,4,5-trimethoxyphenyl)acetyl)oxazolidin-2-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

methyl iodide; In tetrahydrofuran; at -78 ℃; for 1h; Title compound not separated from byproducts;

DOI:10.1021/jm061027h

Reference yield:

(R)-3-((R)-2-(3,4,5-trimethoxyphenyl)propanoyl)-4-isopropyloxazolidin-2-one (931103-13-8) → 2-(3,4,5-trimethoxy-phenyl)-propionaldehyde

Guidance literature:

(R)-3-((R)-2-(3,4,5-trimethoxyphenyl)propanoyl)-4-isopropyloxazolidin-2-one; With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 2h;

With water; ammonium chloride; In dichloromethane; at -78 - 20 ℃;

upstream raw materials:

methyl iodide