(S)-4-[2,2-Bis-(diethoxy-phosphoryl)-ethylcarbamoyl]-2-{4-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-benzoylamino}-butyric acid ethyl ester

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Chemical Name:(S)-4-[2,2-Bis-(diethoxy-phosphoryl)-ethylcarbamoyl]-2-{4-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-benzoylamino}-butyric acid ethyl ester
CAS No.:147938-34-9
Molecular Formula:C₂₈H₄₄Cl₃N₃O₁₂P₂
Molecular Weight:782.977
Hs Code.:

Synonyms:(S)-4-[2,2-Bis-(diethoxy-phosphoryl)-ethylcarbamoyl]-2-{4-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-benzoylamino}-butyric acid ethyl ester

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Chemical Property of (S)-4-[2,2-Bis-(diethoxy-phosphoryl)-ethylcarbamoyl]-2-{4-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-benzoylamino}-butyric acid ethyl ester

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Technology Process of (S)-4-[2,2-Bis-(diethoxy-phosphoryl)-ethylcarbamoyl]-2-{4-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-benzoylamino}-butyric acid ethyl ester

There total 4 articles about (S)-4-[2,2-Bis-(diethoxy-phosphoryl)-ethylcarbamoyl]-2-{4-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-benzoylamino}-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: (4-Chlorocarbonyl-phenyl)-methyl-carbamic acid 2,2,2-trichloro-ethyl ester

: 147938-28-1
N^α--N^δ-<2,2-bis(diethylphosphono)ethyl>glutamine ethyl ester

: 147938-34-9
(S)-4-[2,2-Bis-(diethoxy-phosphoryl)-ethylcarbamoyl]-2-{4-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-benzoylamino}-butyric acid ethyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; for 1h; Ambient temperature;
DOI:10.1016/0223-5234(92)90117-J

Reference yield:

: 56-85-9,26700-71-0
L-glutamine

: 147938-34-9
(S)-4-[2,2-Bis-(diethoxy-phosphoryl)-ethylcarbamoyl]-2-{4-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-benzoylamino}-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / 1 N aq. NaOH / dioxane / 1 h / Ambient temperature

2: 94 percent / diisopropylethylamine / dioxane / 96 h / Ambient temperature

3: 90 percent / potassium tertiobutylate / 2-methyl-propan-2-ol / 1 h / 50 °C

4: 68 percent / triethylamine / tetrahydrofuran / 1 h / Ambient temperature

With sodium hydroxide; potassium tert-butylate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; tert-butyl alcohol;
DOI:10.1016/0223-5234(92)90117-J

Reference yield:

: 13726-85-7
Boc-Gln-OH

: 147938-34-9
(S)-4-[2,2-Bis-(diethoxy-phosphoryl)-ethylcarbamoyl]-2-{4-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-benzoylamino}-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / diisopropylethylamine / dioxane / 96 h / Ambient temperature

2: 90 percent / potassium tertiobutylate / 2-methyl-propan-2-ol / 1 h / 50 °C

3: 68 percent / triethylamine / tetrahydrofuran / 1 h / Ambient temperature

With potassium tert-butylate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; tert-butyl alcohol;
DOI:10.1016/0223-5234(92)90117-J