(2E)-1-(3',4',5'-trimethoxyphenyl)-3-(3-nitrophenyl)-2-propen-1-one

Base Information

• Chemical Name: (2E)-1-(3',4',5'-trimethoxyphenyl)-3-(3-nitrophenyl)-2-propen-1-one
• CAS No.: 127034-05-3
• Molecular Formula: C₁₈H₁₇NO₆
• Molecular Weight: 343.336
• Mol file: 127034-05-3.mol

Synonyms:(2E)-1-(3',4',5'-trimethoxyphenyl)-3-(3-nitrophenyl)-2-propen-1-one

Chemical Property of (2E)-1-(3',4',5'-trimethoxyphenyl)-3-(3-nitrophenyl)-2-propen-1-one

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of (2E)-1-(3',4',5'-trimethoxyphenyl)-3-(3-nitrophenyl)-2-propen-1-one

There total 1 articles about (2E)-1-(3',4',5'-trimethoxyphenyl)-3-(3-nitrophenyl)-2-propen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl (3,4,5-trimethoxyphenyl) ketone (1136-86-3) + 3-nitro-benzaldehyde (99-61-6) → (2E)-1-(3',4',5'-trimethoxyphenyl)-3-(3-nitrophenyl)-2-propen-1-one (127034-05-3)

Guidance literature:

With potassium hydroxide; In methanol; at 20 ℃; for 24h;

DOI:10.1016/j.ejmech.2013.02.037

Reference yield: 54.0%

(2E)-1-(3',4',5'-trimethoxyphenyl)-3-(3-nitrophenyl)-2-propen-1-one (127034-05-3) → (4-(3-nitrophenyl)-1H-pyrrol-3-yl)(3,4,5-trimethoxyphenyl)methanone

Guidance literature:

With [(p-methylphenyl)sulfonylmethyl]isonitrile; sodium hydride; In diethyl ether; dimethyl sulfoxide; mineral oil; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.ejmech.2019.111828

Reference yield:

(2E)-1-(3',4',5'-trimethoxyphenyl)-3-(3-nitrophenyl)-2-propen-1-one (127034-05-3) → (1-(4-aminophenyl)-4-(3-nitrophenyl)-1H-pyrrol-3-yl)(3,4,5-trimethoxyphenyl)-methanone

Guidance literature:

Multi-step reaction with 2 steps

1: [(p-methylphenyl)sulfonylmethyl]isonitrile; sodium hydride / dimethyl sulfoxide; diethyl ether; mineral oil / 4 h / 20 °C / Inert atmosphere

2: caesium carbonate; copper(l) iodide; 1,10-Phenanthroline / 1,4-dioxane / 24 h / 110 °C / Inert atmosphere

With copper(l) iodide; 1,10-Phenanthroline; [(p-methylphenyl)sulfonylmethyl]isonitrile; sodium hydride; caesium carbonate; In 1,4-dioxane; diethyl ether; dimethyl sulfoxide; mineral oil;

DOI:10.1016/j.ejmech.2019.111828

upstream raw materials:

methyl (3,4,5-trimethoxyphenyl) ketone

3-nitro-benzaldehyde