1-methyl-6-(4-(1-(pyridin-2-yl)piperidin-4-yloxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

Base Information

Chemical Name:1-methyl-6-(4-(1-(pyridin-2-yl)piperidin-4-yloxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile
CAS No.:1315463-05-8
Molecular Formula:C₂₄H₂₀F₃N₇O
Molecular Weight:479.464
Hs Code.:

Synonyms:1-methyl-6-(4-(1-(pyridin-2-yl)piperidin-4-yloxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

Suppliers and Price of 1-methyl-6-(4-(1-(pyridin-2-yl)piperidin-4-yloxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-methyl-6-(4-(1-(pyridin-2-yl)piperidin-4-yloxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-methyl-6-(4-(1-(pyridin-2-yl)piperidin-4-yloxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

There total 10 articles about 1-methyl-6-(4-(1-(pyridin-2-yl)piperidin-4-yloxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1315462-93-1
6-(4-hydroxy-3-(trifluoromethyl)phenyl)-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

: 199117-78-7
N-(2-pyridinyl)-4-hydroxypiperidine

: 1315463-05-8
1-methyl-6-(4-(1-(pyridin-2-yl)piperidin-4-yloxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In 1-methyl-pyrrolidin-2-one; at 20 ℃;

Reference yield:

: 50824-04-9
4-bromo-2-(trifluoromethyl)phenol

: 1315463-05-8
1-methyl-6-(4-(1-(pyridin-2-yl)piperidin-4-yloxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran / 0.17 h / 20 °C

1.2: 24 h

2.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 3 h / 80 °C / Inert atmosphere

3.1: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 3 h / 110 °C / Inert atmosphere

4.1: hydrogenchloride; sodium nitrite / 1,4-dioxane; water / 2 h / 0 - 20 °C

5.1: hydrogenchloride; water / tetrahydrofuran / 20 h / 65 °C

6.1: triphenylphosphine; di-isopropyl azodicarboxylate / 1-methyl-pyrrolidin-2-one / 20 °C

With hydrogenchloride; potassium phosphate; di-isopropyl azodicarboxylate; water; potassium acetate; sodium hydride; triphenylphosphine; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; dimethyl sulfoxide;

Reference yield:

: 944388-71-0
4-amino-6-chloro-3-nitropyridine-2-carbonitrile

: 1315463-05-8
1-methyl-6-(4-(1-(pyridin-2-yl)piperidin-4-yloxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / acetonitrile / 5 h / 80 °C

2: tin(II) chloride dihdyrate / ethanol / 3 h / 20 °C

3: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 3 h / 110 °C / Inert atmosphere

4: hydrogenchloride; sodium nitrite / 1,4-dioxane; water / 2 h / 0 - 20 °C

5: hydrogenchloride; water / tetrahydrofuran / 20 h / 65 °C

6: triphenylphosphine; di-isopropyl azodicarboxylate / 1-methyl-pyrrolidin-2-one / 20 °C

With hydrogenchloride; potassium phosphate; tin(II) chloride dihdyrate; di-isopropyl azodicarboxylate; water; potassium carbonate; triphenylphosphine; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; water; acetonitrile;