methyl N-[(benzyloxy)carbonyl]-3-[(2-bromo-7-cyanothieno[3,2-c]pyridin-4-yl)amino]-L-alaninate

Base Information

Chemical Name:methyl N-[(benzyloxy)carbonyl]-3-[(2-bromo-7-cyanothieno[3,2-c]pyridin-4-yl)amino]-L-alaninate
CAS No.:912369-05-2
Molecular Formula:C₂₀H₁₇BrN₄O₄S
Molecular Weight:489.349
Hs Code.:

Synonyms:methyl N-[(benzyloxy)carbonyl]-3-[(2-bromo-7-cyanothieno[3,2-c]pyridin-4-yl)amino]-L-alaninate

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Chemical Property of methyl N-[(benzyloxy)carbonyl]-3-[(2-bromo-7-cyanothieno[3,2-c]pyridin-4-yl)amino]-L-alaninate

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Technology Process of methyl N-[(benzyloxy)carbonyl]-3-[(2-bromo-7-cyanothieno[3,2-c]pyridin-4-yl)amino]-L-alaninate

There total 7 articles about methyl N-[(benzyloxy)carbonyl]-3-[(2-bromo-7-cyanothieno[3,2-c]pyridin-4-yl)amino]-L-alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 690635-43-9
2-bromo-4-chlorothieno[3,2-c]pyridine-7-carbonitrile

: 35761-27-4,96192-93-7
methyl (2S)-3-amino-2-{[(benzyloxy)carbonyl]amino}propanoate hydrochloride

: 912369-05-2
methyl N-[(benzyloxy)carbonyl]-3-[(2-bromo-7-cyanothieno[3,2-c]pyridin-4-yl)amino]-L-alaninate

Guidance literature:: With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 80 ℃; for 2h;

Reference yield:

: 55040-34-1
4-oxo-4,5-dihydrothieno[3,2-c]pyridine-7-carbonitrile

: 912369-05-2
methyl N-[(benzyloxy)carbonyl]-3-[(2-bromo-7-cyanothieno[3,2-c]pyridin-4-yl)amino]-L-alaninate

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; acetic acid / N,N-dimethyl-formamide / 12 h / 80 °C

2: trichlorophosphate / Heating / reflux

3: potassium carbonate / 1-methyl-pyrrolidin-2-one / 2 h / 80 °C

With N-Bromosuccinimide; potassium carbonate; acetic acid; trichlorophosphate; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

Reference yield:

: 20893-30-5
2-cyanomethylthiophene

: 912369-05-2
methyl N-[(benzyloxy)carbonyl]-3-[(2-bromo-7-cyanothieno[3,2-c]pyridin-4-yl)amino]-L-alaninate

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / methanol / 2 h / Heating / reflux

2: oxalyl dichloride / dichloromethane / 1 h / 20 °C

3: sodium azide / 1,4-dioxane; water / 1.5 - 2.5 h / 0 - 20 °C

4: tributyl-amine / diphenylether; dichloromethane / 2.17 h / 210 °C

5: N-Bromosuccinimide; acetic acid / N,N-dimethyl-formamide / 12 h / 80 °C

6: trichlorophosphate / Heating / reflux

7: potassium carbonate / 1-methyl-pyrrolidin-2-one / 2 h / 80 °C

With N-Bromosuccinimide; sodium azide; oxalyl dichloride; tributyl-amine; potassium carbonate; acetic acid; trichlorophosphate; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; diphenylether; dichloromethane; water; N,N-dimethyl-formamide;