methyl N-[(benzyloxy)carbonyl]-3-[(7-cyano-2-phenylthieno[3,2-c]pyridin-4-yl)amino]-L-alaninate

Base Information

Chemical Name:methyl N-[(benzyloxy)carbonyl]-3-[(7-cyano-2-phenylthieno[3,2-c]pyridin-4-yl)amino]-L-alaninate
CAS No.:912369-06-3
Molecular Formula:C₂₆H₂₂N₄O₄S
Molecular Weight:486.551
Hs Code.:

Synonyms:methyl N-[(benzyloxy)carbonyl]-3-[(7-cyano-2-phenylthieno[3,2-c]pyridin-4-yl)amino]-L-alaninate

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Chemical Property of methyl N-[(benzyloxy)carbonyl]-3-[(7-cyano-2-phenylthieno[3,2-c]pyridin-4-yl)amino]-L-alaninate

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Technology Process of methyl N-[(benzyloxy)carbonyl]-3-[(7-cyano-2-phenylthieno[3,2-c]pyridin-4-yl)amino]-L-alaninate

There total 10 articles about methyl N-[(benzyloxy)carbonyl]-3-[(7-cyano-2-phenylthieno[3,2-c]pyridin-4-yl)amino]-L-alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 912369-05-2
methyl N-[(benzyloxy)carbonyl]-3-[(2-bromo-7-cyanothieno[3,2-c]pyridin-4-yl)amino]-L-alaninate

: 98-80-6
phenylboronic acid

: 912369-06-3
methyl N-[(benzyloxy)carbonyl]-3-[(7-cyano-2-phenylthieno[3,2-c]pyridin-4-yl)amino]-L-alaninate

Guidance literature:: With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 80 ℃; for 0.25h;

Reference yield:

: 20893-30-5
2-cyanomethylthiophene

: 912369-06-3
methyl N-[(benzyloxy)carbonyl]-3-[(7-cyano-2-phenylthieno[3,2-c]pyridin-4-yl)amino]-L-alaninate

Guidance literature:: Multi-step reaction with 8 steps

1: potassium carbonate / methanol / 2 h / Heating / reflux

2: oxalyl dichloride / dichloromethane / 1 h / 20 °C

3: sodium azide / 1,4-dioxane; water / 1.5 - 2.5 h / 0 - 20 °C

4: tributyl-amine / diphenylether; dichloromethane / 2.17 h / 210 °C

5: N-Bromosuccinimide; acetic acid / N,N-dimethyl-formamide / 12 h / 80 °C

6: trichlorophosphate / Heating / reflux

7: potassium carbonate / 1-methyl-pyrrolidin-2-one / 2 h / 80 °C

8: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.25 h / 80 °C

With N-Bromosuccinimide; sodium azide; oxalyl dichloride; tributyl-amine; potassium carbonate; caesium carbonate; acetic acid; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; diphenylether; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 912368-69-5
(2Z)-3-cyano-3-(2-thienyl)acryloyl azide

: 912369-06-3
methyl N-[(benzyloxy)carbonyl]-3-[(7-cyano-2-phenylthieno[3,2-c]pyridin-4-yl)amino]-L-alaninate

Guidance literature:: Multi-step reaction with 5 steps

1: tributyl-amine / diphenylether; dichloromethane / 2.17 h / 210 °C

2: N-Bromosuccinimide; acetic acid / N,N-dimethyl-formamide / 12 h / 80 °C

3: trichlorophosphate / Heating / reflux

4: potassium carbonate / 1-methyl-pyrrolidin-2-one / 2 h / 80 °C

5: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.25 h / 80 °C

With N-Bromosuccinimide; tributyl-amine; potassium carbonate; caesium carbonate; acetic acid; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; diphenylether; dichloromethane; water; N,N-dimethyl-formamide;