2-acetyl-7-(3-chloro-propoxy)-benzofuran-4-sulfonic acid [2-(3,4-dimethoxy-phenyl)-ethyl]-amide

Base Information

• Chemical Name: 2-acetyl-7-(3-chloro-propoxy)-benzofuran-4-sulfonic acid [2-(3,4-dimethoxy-phenyl)-ethyl]-amide
• CAS No.: 859708-23-9
• Molecular Formula: C₂₃H₂₆ClNO₇S
• Molecular Weight: 495.981

Synonyms:2-acetyl-7-(3-chloro-propoxy)-benzofuran-4-sulfonic acid [2-(3,4-dimethoxy-phenyl)-ethyl]-amide

Chemical Property of 2-acetyl-7-(3-chloro-propoxy)-benzofuran-4-sulfonic acid [2-(3,4-dimethoxy-phenyl)-ethyl]-amide

Chemical Property:

Purity/Quality:

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Technology Process of 2-acetyl-7-(3-chloro-propoxy)-benzofuran-4-sulfonic acid [2-(3,4-dimethoxy-phenyl)-ethyl]-amide

There total 3 articles about 2-acetyl-7-(3-chloro-propoxy)-benzofuran-4-sulfonic acid [2-(3,4-dimethoxy-phenyl)-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-acetyl-7-(3-chloro-propoxy)-benzofuran-4-sulfonyl chloride + homoveratrylamine hydrochloride (635-85-8) → 2-acetyl-7-(3-chloro-propoxy)-benzofuran-4-sulfonic acid [2-(3,4-dimethoxy-phenyl)-ethyl]-amide (859708-23-9)

Guidance literature:

With triethylamine; In dichloromethane; at 25 ℃;

DOI:10.1039/b503615a

Reference yield:

2-acetyl-7-hydroxybenzofuran (40020-87-9) → 2-acetyl-7-(3-chloro-propoxy)-benzofuran-4-sulfonic acid [2-(3,4-dimethoxy-phenyl)-ethyl]-amide (859708-23-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 71.6 percent / K₂CO₃ / acetone / 2 h / 54 °C

2: chlorosulfonic acid / 26 - 30 °C

3: Et₃N / CH₂Cl₂ / 25 °C

With chlorosulfonic acid; potassium carbonate; triethylamine; In dichloromethane; acetone;

DOI:10.1039/b503615a

Reference yield:

1-[7-(3-chloro-propoxy)-benzofuran-2-yl]-ethanone (859708-18-2) → 2-acetyl-7-(3-chloro-propoxy)-benzofuran-4-sulfonic acid [2-(3,4-dimethoxy-phenyl)-ethyl]-amide (859708-23-9)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorosulfonic acid / 26 - 30 °C

2: Et₃N / CH₂Cl₂ / 25 °C

With chlorosulfonic acid; triethylamine; In dichloromethane;

DOI:10.1039/b503615a

upstream raw materials:

homoveratrylamine hydrochloride

2-acetyl-7-hydroxybenzofuran

1-[7-(3-chloro-propoxy)-benzofuran-2-yl]-ethanone

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