635-85-8

Basic information

• Product Name: 2-(3,4-dimethoxyphenyl)ethanamine
• Synonyms: [2-(3,4-Dimethoxyphenyl)ethyl]amine hydrochloride;2-(3,4-DIMETHOXYPHENYL) ETHANAMINE HYDROCHLORIDE;3,4-Dimethoxyphenethylamine hydrochloride;beta-(3,4-Dimethoxyphenyl)ethylamine hydrochloride
• CAS NO: 635-85-8
• Molecular Formula: C₁₀H₁₅NO₂*ClH
• Molecular Weight: 217.6925
• Mol File: 635-85-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 195-196℃ (ethanol )
• Boiling Point: 324.1 °C at 760 mmHg
• Flash Point: 132.8 °C
• Appearance: /
• Vapor Pressure: 0.000251mmHg at 25°C
• CAS DataBase Reference: 2-(3,4-dimethoxyphenyl)ethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-dimethoxyphenyl)ethanamine(635-85-8)
• EPA Substance Registry System: 2-(3,4-dimethoxyphenyl)ethanamine(635-85-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 635-85-8(Hazardous Substances Data)

Usage

Description

3,4-Dimethoxyphenethylamine (hydrochloride) (Item No. 14141) is an analytical reference standard that is structurally categorized as a phenethylamine. It inhibits the deamination of tyramine and tryptamine by rat brain monoamine oxidase. This product is intended for research and forensic applications.

Uses

2-(3,4-dimethoxyphenyl)ethanamine hydrochloride (cas# 635-85-8) is used as a catalyst for cyclocondensation reactions of dihydroisoquinoline with acylcycloalkenes.

InChI:InChI=1/C10H15NO2.ClH/c1-12-9-4-3-8(5-6-11)7-10(9)13-2;/h3-4,7H,5-6,11H2,1-2H3;1H

Upstream product

• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 70360-83-7 1,2-dimethoxy-4-(2-nitroethyl)benzene 
• 4230-93-7 3,4-dimethoxynitrostyrene 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Downstream Products

• 63375-81-5 2-(2-bromo-4,5-dimethoxyphenylphenyl)ethan-1-amine 
• 25017-47-4 N-<2-(3,4-dimethoxyphenylethyl)>urea 
• 67191-53-1 N-(3,4-Dimethoxyphenethyl)propionamide 
• 81165-56-2 N-(3,4-Dimethoxyphenethyl)butyramide 
• 97796-96-8 N-(3,4-dimethoxyphenethyl)pentanamide 
• 6275-29-2 N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide 
• 645-31-8 3-hydroxytyramine hydrobromide 
• 1307816-08-5 4-bromo-3-(3-nitrophenoxy)-1-phenethyl-1,5-dihydropyrrol-2-one 
• 1206698-58-9 C₁₆H₁₉NO₅ 
• 56435-44-0 (+/-)-yenhusomidine 
• 128308-49-6 8,9-dimethoxy-10b-phenyl-1,2,5,6,11,12-hexahydro-10bH-imidazo<1',2':1,2>pyrimido<4,3-a>isoquinoline 
• 128308-68-9 3-{2-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-4,5-dihydro-imidazol-1-yl}-1-phenyl-propan-1-one 
• 128308-48-5 1-<2-(3,4-dimethoxyphenyl)ethyl>-2-benzylidene-2,3,5,6-tetrahydro-1H-imidazo<1,2-a>imidazole 
• 112331-83-6 1-Cinnamyl-2-<2-(3,4-dimethoxyphenyl)ethylamino>imidazoline 

Relevant articles and documents

Phosphine-Free Manganese Catalyst Enables Selective Transfer Hydrogenation of Nitriles to Primary and Secondary Amines Using Ammonia-Borane

Herein we report the synthesis of primary and secondary amines by nitrile hydrogenation, employing a borrowing hydrogenation strategy. A class of phosphine-free manganese(I) complexes bearing sulfur side arms catalyzed the reaction under mild reaction conditions, where ammonia-borane is used as the source of hydrogen. The synthetic protocol is chemodivergent, as the final product is either primary or secondary amine, which can be controlled by changing the catalyst structure and the polarity of the reaction medium. The significant advantage of this method is that the protocol operates without externally added base or other additives as well as obviates the use of high-pressure dihydrogen gas required for other nitrile hydrogenation reactions. Utilizing this method, a wide variety of primary and symmetric and asymmetric secondary amines were synthesized in high yields. A mechanistic study involving kinetic experiments and high-level DFT computations revealed that both outer-sphere dehydrogenation and inner-sphere hydrogenation were predominantly operative in the catalytic cycle.

Synthetic method of high-purity dopamine hydrochloride

The invention provides a synthetic method of dopamine hydrochloride, and belongs to the field of drug synthesis. The preparation method comprises the following steps: taking 3,4-dimethoxyphenylethylamine as an initial raw material, firstly reacting with an acid to form a salt, re-crystallizing and refining to obtain 3,4-dimethoxyphenylethylamine salt, reacting with hydrobromic acid to remove methyl to generate dopamine hydrobromide, and finally reacting with hydrochloric acid to form a salt so as to obtain dopamine hydrochloride. The preparation method provided by the invention has the advantages of cheap and easily available initial raw materials, simple process, no high-temperature and high-pressure hydrogenation step, low cost, high purity and high yield, and is suitable for industrialproduction.

Enhanced copper-mediated 18F-fluorination of aryl boronic esters provides eight radiotracers for PET applications

[18F]FMTEB, [18F]FPEB, [18F]flumazenil, [18F]DAA1106, [18F]MFBG, [18F]FDOPA, [18F]FMT and [18F]FDA are prepared from the corresponding arylboronic esters and [18