t-butyl 4-nitro-3-[N-(t-butyloxycarbonyl)-N-(2-phenyl-ethyl)aminomethyl]benzoate

Base Information

• Chemical Name: t-butyl 4-nitro-3-[N-(t-butyloxycarbonyl)-N-(2-phenyl-ethyl)aminomethyl]benzoate
• CAS No.: 147290-69-5
• Molecular Formula: C₂₅H₃₂N₂O₆
• Molecular Weight: 456.539
• Mol file: 147290-69-5.mol

Synonyms:t-butyl 4-nitro-3-[N-(t-butyloxycarbonyl)-N-(2-phenyl-ethyl)aminomethyl]benzoate

Chemical Property of t-butyl 4-nitro-3-[N-(t-butyloxycarbonyl)-N-(2-phenyl-ethyl)aminomethyl]benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of t-butyl 4-nitro-3-[N-(t-butyloxycarbonyl)-N-(2-phenyl-ethyl)aminomethyl]benzoate

There total 7 articles about t-butyl 4-nitro-3-[N-(t-butyloxycarbonyl)-N-(2-phenyl-ethyl)aminomethyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + t-butyl 4-nitro-3-[N-(2-phenylethyl)aminomethyl]benzoate (147290-68-4) → t-butyl 4-nitro-3-[N-(t-butyloxycarbonyl)-N-(2-phenyl-ethyl)aminomethyl]benzoate (147290-69-5)

Guidance literature:

In dichloromethane;

DOI:10.1021/jm00001a003

Reference yield:

3-methyl-4-nitrobenzoic acid (3113-71-1) → t-butyl 4-nitro-3-[N-(t-butyloxycarbonyl)-N-(2-phenyl-ethyl)aminomethyl]benzoate (147290-69-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / PhSO₂Cl, pyridine

2: N-bromosuccinimide, (PhCO₂)2 / CCl₄ / Heating

3: NaHCO₃ / tetrahydrofuran

4: 100 percent / CH₂Cl₂

With pyridine; N-Bromosuccinimide; sodium hydrogencarbonate; benzenesulfonyl chloride; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane;

DOI:10.1021/jm00001a003

Reference yield:

phenethylamine (64-04-0) → t-butyl 4-nitro-3-[N-(t-butyloxycarbonyl)-N-(2-phenyl-ethyl)aminomethyl]benzoate (147290-69-5)

Guidance literature:

Multi-step reaction with 2 steps

1: NaHCO₃ / tetrahydrofuran

2: 100 percent / CH₂Cl₂

With sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00001a003

upstream raw materials:

di-tert-butyl dicarbonate

t-butyl 4-nitro-3-[N-(2-phenylethyl)aminomethyl]benzoate

3-methyl-4-nitrobenzoic acid

phenethylamine

Downstream raw materials:

tert-butyl 4-amino-3-[[N-(tert-butoxycarbonyl)-N-phenethylamino]methyl]benzoate

methyl 7-carboxy-3-oxo-1,4-benzodiazepine-2-acetate

[7-(4-Carbamimidoyl-phenylcarbamoyl)-3-oxo-4-phenethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl]-acetic acid methyl ester

2-{4-tert-Butoxycarbonyl-2-[(tert-butoxycarbonyl-phenethyl-amino)-methyl]-phenylamino}-succinic acid dimethyl ester