5,6-dihydro-2-(4-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one

Base Information

• Chemical Name: 5,6-dihydro-2-(4-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one
• CAS No.: 1567375-96-5
• Molecular Formula: C₂₁H₁₉FN₆O₂
• Molecular Weight: 406.419

Synonyms:5,6-dihydro-2-(4-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one

Chemical Property of 5,6-dihydro-2-(4-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one

Chemical Property:

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Technology Process of 5,6-dihydro-2-(4-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one

There total 3 articles about 5,6-dihydro-2-(4-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

1-azido-2-fluoroethane (894792-94-0) + 5,6-dihydro-2-(4-(prop-2-ynyloxy)phenyl)-imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one (1567375-94-3) → 5,6-dihydro-2-(4-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one (1567375-96-5)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In N,N-dimethyl-formamide; at 23 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2014.01.019

Reference yield: 72.0%

→ 5,6-dihydro-2-(4-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one (1567375-96-5)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In N,N-dimethyl-formamide; at 23 ℃;

Reference yield:

4-(prop-2-yn-1-yloxy)benzoyl chloride (96327-77-4) + 9-amino-1,2,3,4-tetrahydro-5H-benzo[e][1,4]diazepin-5-one (328546-66-3) → 5,6-dihydro-2-(4-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one (1567375-96-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloromethane; pyridine / 23 °C / Inert atmosphere

1.2: 3 h / Reflux; Inert atmosphere

2.1: sodium L-ascorbate; copper(ll) sulfate pentahydrate / N,N-dimethyl-formamide / 23 °C / Inert atmosphere

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In pyridine; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2014.01.019

upstream raw materials:

1-azido-2-fluoroethane

5,6-dihydro-2-(4-(prop-2-ynyloxy)phenyl)-imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one

4-(prop-2-yn-1-yloxy)benzoyl chloride

9-amino-1,2,3,4-tetrahydro-5H-benzo[e][1,4]diazepin-5-one

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